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Stentzel, S.* ; Hagl, B. ; Abel, F.* ; Kahl, B.C.* ; Rack-Hoch, A.* ; Broeker, B.M.* ; Renner, E.D.

Reduced immunoglobulin (Ig) G response to Staphylococcus aureus in STAT3 hyper-IgE syndrome.

Clin. Infect. Dis. 64, 1279-1282 (2017)
Publ. Version/Full Text DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
STAT3 hyper-IgE syndrome (STAT3-HIES) patients presented with significantly lower Staphylococcus aureus-specific serum IgG compared to cystic fibrosis patients despite recurrent S. aureus infections. Immunoglobulin replacement therapy increased S. aureus-specific IgG in STAT3-HIES patients and attenuated the clinical course of disease suggesting a role of humoral immunity in S. aureus clearance.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords S. Aureus ; Stat3 ; Hyper-ige Syndrome ; Hies ; Th17 ; Cystic Fibrosis ; Adaptive Immunity ; Specific Igg; Signal Transducer; Mutations; Infections; Activator; Vaccine; Cells
ISSN (print) / ISBN 1058-4838
e-ISSN 1537-6591
Quellenangaben Volume: 64, Issue: 9, Pages: 1279-1282 Article Number: , Supplement: ,
Publisher Oxford University Press
Publishing Place Cary, NC
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Environmental Medicine (IEM)