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Assessing systems properties of yeast mitochondria through an interaction map of the organelle.
PLoS Genet. 2, 1612-1624:e170 (2006)
Mitochondria carry out specialized functions; compartmentalized, yet integrated into the metabolic and signaling processes of the cell. Although many mitochondrial proteins have been identified, understanding their functional interrelationships has been a challenge. Here we construct a comprehensive network of the mitochondrial system. We integrated genome-wide datasets to generate an accurate and inclusive mitochondrial parts list. Together with benchmarked measures of protein interactions, a network of mitochondria was constructed in their cellular context, including extra-mitochondrial proteins. This network also integrates data from different organisms to expand the known mitochondrial biology beyond the information in the existing databases. Our network brings together annotated and predicted functions into a single framework. This enabled, for the entire system, a survey of mutant phenotypes, gene regulation, evolution, and disease susceptibility. Furthermore, we experimentally validated the localization of several candidate proteins and derived novel functional contexts for hundreds of uncharacterized proteins. Our network thus advances the understanding of the mitochondrial system in yeast and identifies properties of genes underlying human mitochondrial disorders.
Impact Factor
Scopus SNIP
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Times Cited
Times Cited
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0.200
0.000
60
61
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
PROTEIN-PROTEIN INTERACTIONS; SACCHAROMYCES-CEREVISIAE; CYTOCHROME-C; COPPER DETOXIFICATION; INTEGRATIVE GENOMICS; MASS-SPECTROMETRY; DISEASE GENES; EXPRESSION; NETWORKS; IDENTIFICATION
Language
english
Publication Year
2006
HGF-reported in Year
0
ISSN (print) / ISBN
1553-7390
e-ISSN
1553-7404
Journal
PLoS Genetics
Quellenangaben
Volume: 2,
Issue: 10,
Pages: 1612-1624,
Article Number: e170
Publisher
Public Library of Science (PLoS)
Reviewing status
Peer reviewed
Institute(s)
Institute of Human Genetics (IHG)
POF-Topic(s)
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-500700-001
PubMed ID
17054397
WOS ID
WOS:000241922200011
Scopus ID
33750491220
Erfassungsdatum
2006-12-31