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Plath, N.* ; Ohana, O.* ; Dammermann, B.* ; Errington, M.L.* ; Schmitz, D.* ; Gross, C.* ; Mao, X.* ; Engelsberg, A.* ; Mahlke, C.* ; Welzl, H.* ; Kobalz, U.* ; Stawrakakis, A.* ; Fernandez, E.* ; Waltereit, R.* ; Bick-Sander, A.* ; Therstappen, E.* ; Cooke, S.F.* ; Blanquet, V. ; Wurst, W. ; Salmen, B.* ; Bösl, M.R.* ; Lipp, H.P.* ; Grant, S.G.* ; Bliss, T.V.* ; Wolfer, D.P.* ; Kuhl, D.*

Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.

Neuron 52, 437-444 (2006)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and explicit learning tasks, despite intact short-term memory. Moreover, they exhibit a biphasic alteration of hippocampal long-term potentiation in the dentate gyrus and area CA1 with an enhanced early and absent late phase. In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage. © 2006 Elsevier Inc. All rights reserved.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Proteins ; Signaling ; Sysneuro
ISSN (print) / ISBN 0896-6273
e-ISSN 1097-4199
Journal Neuron
Quellenangaben Volume: 52, Issue: 3, Pages: 437-444 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Cambridge, Mass.
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)