PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Ventura-Clapier, R.* ; Dworatzek, E.* ; Seeland, U.* ; Kararigas, G.* ; Francois Arnal, J.* ; Brunelleschi, S.* ; Carpenter, T.* ; Erdmann, J.* ; Franconi, F.* ; Giannetta, E.* ; Glezerman, M.* ; Hofmann, S.M. ; Junien, C.* ; Katai, M.* ; Kublickiene, K.* ; König, I.R.* ; Majdic, G.* ; Malorni, W.* ; Mieth, C.* ; Miller, V.* ; Reynolds, R.* ; Shimokawa, H.* ; Tannenbaum, C.* ; Maria Anna, D.U.* ; Regitz-Zagrosek, V.*

Sex in basic research - Concepts in the cardiovascular field.

Cardiovasc. Res. 113, 711-724 (2017)
Publ. Version/Full Text DOI PMC
Closed
Open Access Green as soon as Postprint is submitted to ZB.
Women and men, female and male animals and cells are biologically different, and acknowledgement of this fact is critical to advancing medicine. However, incorporating concepts of sex-specific analysis in basic research is largely neglected, introducing bias into translational findings, clinical concepts and drug development. Research funding agencies recently approached these issues but implementation of policy changes in the scientific community is still limited, probably due to deficits in concepts, knowledge and proper methodology.This expert review is based on the EUGenMed project (www.eugenmed.eu) developing a roadmap for implementing sex and gender in biomedical and health research. For sake of clarity and conciseness, examples are mainly taken from the cardiovascular field that may serve as a paradigm for others, since a significant amount of knowledge how sex and estrogen determine the manifestation of many cardiovascular diseases (CVD) has been accumulated. As main concepts for implementation of sex in basic research, the study of primary cell and animals of both sexes, the study of the influence of genetic versus hormonal factors and the analysis of sex chromosomes and sex specific statistics in genome wide association studies (GWAS) are discussed. The review also discusses methodological issues, and analyses strength, weaknesses, opportunities and threats in implementing sex-sensitive aspects into basic research.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
5.878
0.000
74
84
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Animal Models ; Basic Research ; Cardiac Cell Models ; Chromosomes ; Hormones ; Sex; Estrogen-receptor-alpha; Aortic-valve-replacement; Dna Methylation; Heart-failure; Dependent Regulation; Pressure-overload; Gene-expression; Myocardial Hypertrophy; Biomedical-research; Gender Perspective
Language english
Publication Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 0008-6363
e-ISSN 1755-3245
Journal Cardiovascular Research
Quellenangaben Volume: 113, Issue: 7, Pages: 711-724 Article Number: , Supplement: ,
Publisher Oxford University Press
Publishing Place Oxford
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Regeneration Research (IDR)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502390-001
DOI 10.1093/cvr/cvx066
WOS ID WOS:000404611900006
Scopus ID 85027309513
PubMed ID 28472454
Erfassungsdatum 2017-05-30
[➜Report correction]