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Schaub, A. ; Glasmacher, E.

Splicing in immune cells - mechanistic insights and emerging topics.

Int. Immunol. 29, 173-181 (2017)
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Differential splicing of mRNAs not only enables regulation of gene expression levels, but also ensures a high degree of gene-product diversity. The extent to which splicing of mRNAs is utilized as a mechanism in immune cells has become evident within the last few years. Still, only a few of these mechanisms have been well studied. In this review we discuss some of the best-understood mechanisms, for instance the differential splicing of CD45 in T cells, as well as immunoglobulin genes in B cells. Beyond that we provide general mechanistic insights on how, when and where this process takes place and discuss the current knowledge regarding these topics in immune cells. We also highlight some of the reported links to immune-related diseases, genome-wide sequencing studies that revealed thousands of differentially spliced transcripts, as well as splicing studies on immune cells that remain mechanistically not fully understood. We thereby display potential emerging topics for future studies centered on splicing mechanisms in immune cells.
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Publication type Article: Journal article
Document type Scientific Article
Keywords B Cells ; T Cells ; Alternative Splicing ; Nuclear Bodies ; Sequencing; Rna-polymerase-ii; Speckle-related Protein; Secretory Poly(a) Site; Acute Myeloid-leukemia; Messenger-rna; T-cell; Dna Rearrangement; Sequence-analysis; Mammalian-cells; Molecular-basis
Language
Publication Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 0953-8178
e-ISSN 1460-2377
Journal International Immunology
Quellenangaben Volume: 29, Issue: 4, Pages: 173-181 Article Number: , Supplement: ,
Publisher Oxford University Press
Publishing Place Oxford
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-501900-226
DOI 10.1093/intimm/dxx026
WOS ID WOS:000404457800005
Scopus ID 85021355924
PubMed ID 28498981
Erfassungsdatum 2017-07-10
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