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Interconnection between DNA damage, senescence, inflammation, and cancer.
Front. Biosci. 22, 348-369 (2017)
In order to deal with endogenous and exogenous factors, including radiation or pathogens, cells evolved different strategies. This includes highly complex processes such as DNA damage response, senescence, cell death, and inflammatory reactions. Recent research indicates an interconnection between the mentioned cellular pathways whilst all of them seem to play a role in induction and progression, but also the prevention of cancerous diseases and therefore qualify for potential prevention and treatment strategies. On the basis of their pivotal functions in cancer biology in general, each of the cellular processes represents promising single therapeutic targets. Further, due to their strong interconnection, targeting all of them in a multimodal approach could be another promising strategy to treat cancer. We, therefore, review the mechanisms of DNA damage induction, detection and repair as well as the induction of cell death. Further, features of senescence and mechanism of inflammation induction and abrogation are outlined. A special focus is set on how senescence and inflammation are related to diseases and how targeting them could contribute to improvement of cancer therapies.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
2017
HGF-reported in Year
2017
ISSN (print) / ISBN
1093-9946
e-ISSN
1093-4715
Journal
Frontiers in Bioscience
Quellenangaben
Volume: 22,
Pages: 348-369
Publisher
Frontiers
Reviewing status
Peer reviewed
Institute(s)
Translational Metabolic Oncology (IDC-TMO)
POF-Topic(s)
30203 - Molecular Targets and Therapies
Research field(s)
Radiation Sciences
PSP Element(s)
G-501000-001
PubMed ID
27814618
Erfassungsdatum
2017-05-22