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Hybrid ultrasound and dual-wavelength optoacoustic biomicroscopy for functional neuroimaging.
Proc. SPIE 10064:100644T (2017)
Many neurological disorders are linked to abnormal activation or pathological alterations of the vasculature in the affected brain region. Obtaining simultaneous morphological and physiological information of neurovasculature is very challenging due to the acoustic distortions and intense light scattering by the skull and brain. In addition, the size of cerebral vasculature in murine brains spans an extended range from just a few microns up to about a millimeter, all to be recorded in 3D and over an area of several dozens of mm2. Numerous imaging techniques exist that excel at characterizing certain aspects of this complex network but are only capable of providing information on a limited spatiotemporal scale. We present a hybrid ultrasound and dual-wavelength optoacoustic microscope, capable of rapid imaging of murine neurovasculature in-vivo, with high spatial resolution down to 12 μm over a large field of view exceeding 50mm2. The dual wavelength imaging capability allows for the visualization of functional blood parameters through an intact skull while pulse-echo ultrasound biomicroscopy images are captured simultaneously by the same scan head. The flexible hybrid design in combination with fast high-resolution imaging in 3D holds promise for generating better insights into the architecture and function of the neurovascular system.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Brain Imaging ; Cerebral Vasculature ; Multiwavelength ; Neuroimaging ; Neurovasculature ; Photoacoustic
Language
english
Publication Year
2017
HGF-reported in Year
2017
ISSN (print) / ISBN
0277-786X
e-ISSN
1996-756X
Conference Title
Photons Plus Ultrasound: Imaging and Sensing 2017
Conference Date
29 January - 1 February 2017
Conference Location
San Diego, California United States
Journal
Proceedings of SPIE
Quellenangaben
Volume: 10064,
Article Number: 100644T
Publisher
SPIE
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s)
30205 - Bioengineering and Digital Health
Research field(s)
Enabling and Novel Technologies
PSP Element(s)
G-505590-001
Scopus ID
85019259782
Erfassungsdatum
2017-06-06