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Reply to "Tolerogenic insulin peptide therapy precipitates type 1 diabetes".
J. Exp. Med. 214, 2157-2159 (2017)
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DOI
PMC
In this issue of JEM, Bergman et al. (https://doi.org/10.1084/jem.20160471) challenge the data published in our previous JEM paper on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Here, we provide a response to these data and suggest that appropriate subimmunogenic conditions are required to induce Foxp3(+) regulatory T cell conversion.
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Publication type
Article: Journal article
Document type
Letter to the Editor
Keywords
Nod Mouse; T-cells; In-vivo; Differentiation; Vaccination; Microbiota; Antigen; Mtor; Akt
ISSN (print) / ISBN
0022-1007
e-ISSN
1540-9538
Journal
Journal of Experimental Medicine
Quellenangaben
Volume: 214,
Issue: 7,
Pages: 2157-2159
Publisher
Rockefeller University Press
Publishing Place
New York
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Type 1 Diabetes Immunology (TDI)