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Daniel, C. ; Weigmann, B.* ; von Boehmer, H.*

Reply to "Tolerogenic insulin peptide therapy precipitates type 1 diabetes".

J. Exp. Med. 214, 2157-2159 (2017)
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In this issue of JEM, Bergman et al. (https://doi.org/10.1084/jem.20160471) challenge the data published in our previous JEM paper on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Here, we provide a response to these data and suggest that appropriate subimmunogenic conditions are required to induce Foxp3(+) regulatory T cell conversion.
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Publication type Article: Journal article
Document type Letter to the Editor
Keywords Nod Mouse; T-cells; In-vivo; Differentiation; Vaccination; Microbiota; Antigen; Mtor; Akt
Language english
Publication Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 0022-1007
e-ISSN 1540-9538
Quellenangaben Volume: 214, Issue: 7, Pages: 2157-2159 Article Number: , Supplement: ,
Publisher Rockefeller University Press
Publishing Place New York
Reviewing status Peer reviewed
Institute(s) Research Unit Type 1 Diabetes Immunology (TDI)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502191-001
Scopus ID 85021886112
PubMed ID 28536240
Erfassungsdatum 2017-07-12