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McKay, J.D.* ; Hung, R.J.* ; Han, Y.* ; Zong, X.* ; Carreras-Torres, R.* ; Christiani, D.C.* ; Caporaso, N.E.* ; Johansson, M.* ; Xiao, X.* ; Li, Y.* ; Byun, J.* ; Dunning, A.M.* ; Pooley, K.A.* ; Qian, D.C.* ; Ji, X.* ; Liu, G.* ; Timofeeva, M.N.* ; Bojesen, S.E.* ; Wu, X.* ; Le Marchand, L.* ; Albanes, D.* ; Bickeböller, H.* ; Aldrich, M.C.* ; Bush, W.S.* ; Tardón, A.* ; Rennert, G.* ; Teare, M.D.* ; Field, J.K.* ; Kiemeney, L.A.* ; Lazarus, P.* ; Haugen, A.* ; Lam, S.* ; Schabath, M.B.* ; Andrew, A.S.* ; Shen, H.* ; Hong, Y.C.* ; Yuan, J.M.* ; Bertazzi, P.A.* ; Pesatori, A.C.* ; Ye, Y.* ; Diao, N.* ; Su, L.* ; Zhang, R.* ; Brhane, Y.* ; Leighl, N.* ; Johansen, J.S.* ; Mellemgaard, A.* ; Saliba, W.* ; Haiman, C.A.* ; Wilkens, L.R.* ; Fernández-Somoano, A.* ; Fernandez-Tardon, G.* ; van der Heijden, H.F.M.* ; Kim, J.H.* ; Dai, J.C.* ; Hu, Z.* ; Davies, M.P.A.* ; Marcus, M.W.* ; Brunnström, H.* ; Manjer, J.* ; Melander, O.* ; Müller, D.C.* ; Overvad, K.* ; Trichopoulou, A.* ; Tumino, R.* ; Doherty, J.A.* ; Barnett, M.P.* ; Chen, C.* ; Goodman, G.E.* ; Cox, A.* ; Taylor, F.* ; Woll, P.* ; Brüske, I. ; Wichmann, H.-E. ; Manz, J. ; Muley, T.R.* ; Risch, A.* ; Rosenberger, A.* ; Grankvist, K.* ; Shepherd, F.A.* ; Tsao, M.S.* ; Arnold, S.M.* ; Haura, E.B.* ; Bolca, C.* ; Holcatova, I.* ; Janout, V.* ; Kontic, M.* ; Lissowska, J.* ; Mukeria, A.* ; Ognjanovic, S.* ; Orlowski, T.M.* ; Scelo, G.* ; Swiatkowska, B.* ; Zaridze, D.* ; Bakke, P.* ; Skaug, V.* ; Zienolddiny, S.* ; Duell, E.J.* ; Butler, L.M.* ; Koh, W.P.* ; Gao, Y.T.* ; Houlston, R.S.* ; McLaughlin, J.* ; Stevens, V.L.* ; Joubert, P.* ; Lamontagne, M.* ; Nickle, D.C.* ; Obeidat, M.* ; Timens, W.* ; Zhu, B.* ; Song, L.* ; Kachuri, L.* ; Artigas, M.S.* ; Tobin, M.D.* ; Wain, L.V.* ; Rafnar, T.* ; Thorgeirsson, T.E.* ; Reginsson, G.W.* ; Stefansson, K.* ; Hancock, D.B.* ; Bierut, L.J.* ; Spitz, M.R.* ; Gaddis, N.C.* ; Lutz, S.M.* ; Gu, F.* ; Johnson, E.O.* ; Kamal, A.K.* ; Pikielny, C.* ; Zhu, D.* ; Lindströem, S.* ; Jiang, X.* ; Tyndale, R.F.* ; Chenevix-Trench, G.* ; Beesley, J.* ; Bossé, Y.* ; Chanock, S.* ; Brennan, P.* ; Landi, M.T.* ; Amos, C.I.*

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

Nat. Genet. 49, 1126-1132 (2017)
Postprint DOI PMC
Open Access Green
Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genome-wide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Genome-wide Association; Telomere Length; Crohns-disease; Common Cancers; Glioma Risk; Variants; Imputation; Architecture; Metaanalysis; Consortium
Language english
Publication Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 49, Issue: 7, Pages: 1126-1132 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
80000 - German Center for Lung Research
30503 - Chronic Diseases of the Lung and Allergies
Research field(s) Genetics and Epidemiology
Lung Research
PSP Element(s) G-504000-008
G-504000-009
G-504091-001
G-501800-392
G-503900-001
DOI 10.1038/ng.3892
WOS ID WOS:000404253300024
Scopus ID 85020451435
PubMed ID 28604730
Erfassungsdatum 2017-07-14
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