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Adipose tissue: Between the extremes.
EMBO J. 36, 1999-2017 (2017)
Publ. Version/Full Text
DOI
PMC
Adipose tissue represents a critical component in healthy energy homeostasis. It fulfills important roles in whole-body lipid handling, serves as the body's major energy storage compartment and insulation barrier, and secretes numerous endocrine mediators such as adipokines or lipokines. As a consequence, dysfunction of these processes in adipose tissue compartments is tightly linked to severe metabolic disorders, including obesity, metabolic syndrome, lipodystrophy, and cachexia. While numerous studies have addressed causes and consequences of obesity-related adipose tissue hypertrophy and hyperplasia for health, critical pathways and mechanisms in (involuntary) adipose tissue loss as well as its systemic metabolic consequences are far less understood. In this review, we discuss the current understanding of conditions of adipose tissue wasting and review microenvironmental determinants of adipocyte (dys)function in related pathophysiologies.
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Publication type
Article: Journal article
Document type
Review
Keywords
Adipose Tissue Dysfunction ; Cachexia ; Lipodystrophy ; Metabolic Disorders ; Obesity; Activated Protein-kinase; Congenital Generalized Lipodystrophy; Induced Insulin-resistance; Familial Partial Lipodystrophy; Leptin-replacement Therapy; Cancer-associated Cachexia; Tumor-bearing Rats; High-fat-diet; Extracellular-matrix; Metabolic Dysfunction
ISSN (print) / ISBN
0261-4189
e-ISSN
1460-2075
Journal
EMBO Journal, The
Quellenangaben
Volume: 36,
Issue: 14,
Pages: 1999-2017
Publisher
Wiley
Publishing Place
Heidelberg, Germany
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Cancer (IDC)