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Schwarz, M. ; Soliman, D. ; Omar, M. ; Bühler, A. ; Ovsepian, S.V. ; Aguirre, J. ; Ntziachristos, V.

Optoacoustic dermoscopy of the human skin: Tuning excitation energy for optimal detection bandwidth with fast and deep imaging in vivo.

IEEE Trans. Med. Imaging 36, 1287-1296 (2017)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Optoacoustic (photoacoustic) dermoscopy offers two principal advantages over conventional optical imaging applied in dermatology. First, it yields high-resolution cross-sectional images of the skin at depths not accessible to other non-invasive optical imaging methods. Second, by resolving absorption spectra at multiple wavelengths, it enables label-free three-dimensional visualization of morphological and functional features. However, the relation of pulse energy to generated bandwidth and imaging depth remains poorly defined. In this study, we apply computer models to investigate the optoacoustic frequency response generated by simulated skin. We relate our simulation results to experimental measurements of the detection bandwidth as a function of optical excitation energy in phantoms and human skin. Using raster-scan optoacoustic mesoscopy (RSOM), we further compare the performance of two broadband ultrasonic detectors (bandwidth of 20-180 MHz and 10-90 MHz) in acquiring optoacoustic readouts. Based on the findings of this study, we propose energy ranges required for skin imaging with considerations of laser safety standards.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Angiographic Imaging ; Evaluation And Performance ; Image Quality Assessment ; Optimization ; Optoacoustic/photo-acoustic Imaging ; Skin ; Tissue Modelling ; Vessels ; Visualization
ISSN (print) / ISBN 0278-0062
e-ISSN 1558-254X
Journal IEEE Transactions on Medical Imaging
Quellenangaben Volume: 36, Issue: 6, Pages: 1287-1296 Article Number: , Supplement: ,
Publisher Institute of Electrical and Electronics Engineers (IEEE)
Publishing Place New York, NY [u.a.]
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)