PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Christophersen, I.E.* ; Rienstra, M.* ; Roselli, C. ; Yin, X.* ; Geelhoed, B.* ; Barnard, J.* ; Lin, H.* ; Arking, D.E.* ; Smith, A.V.* ; Albert, C.M.* ; Chaffin, M.* ; Tucker, N.R.* ; Li, M.* ; Klarin, D.* ; Bihlmeyer, N.A.* ; Low, S.K.* ; Weeke, P.E.* ; Müller-Nurasyid, M. ; Smith, J.G.* ; Brody, J.A.* ; Niemeijer, M.N.* ; Doerr, M.* ; Trompet, S.* ; Huffman, J.* ; Gustafsson, S.* ; Schurmann, C.* ; Kleber, M.E.* ; Lyytikäinen, L.-P.* ; Seppälä, I.* ; Malik, R.* ; Horimoto, A.R.V.R.* ; Perez, M.L.* ; Sinisalo, J.* ; Aeschbacher, S.* ; Theriault, S.* ; Yao, J.* ; Radmanesh, F.* ; Weiss, S.* ; Teumer, A.* ; Choi, S.H.* ; Weng, L.* ; Clauss, S.* ; Deo, R.* ; Rader, D.J.* ; Shah, S.H.* ; Sun, A.* ; Hopewell, J.C.* ; Debette, S.* ; Chauhan, G.* ; Yang, Q.* ; Worrall, B.B.* ; Paré, G.* ; Kamatani, Y.* ; Hagemeijer, Y.P.* ; Verweij, N.* ; Siland, J.E.* ; Kubo, M.* ; Smith, J.D.* ; van Wagoner, D.R.* ; Bis, J.C.* ; Perz, S. ; Psaty, B.M.* ; Ridker, P.M.* ; Magnani, J.W.* ; Harris, T.B.* ; Launer, L.J.* ; Shoemaker, M.B.* ; Padmanabhan, S.* ; Haessler, J.* ; Bartz, T.M.* ; Waldenberger, M. ; Lichtner, P. ; Arendt, M.* ; Krieger, J.E.* ; Kähönen, M.* ; Risch, L.* ; Mansur, A.J.* ; Peters, A. ; Smith, B.H.* ; Lind, L.* ; Scott, S.A.* ; Lu, Y.* ; Bottinger, E.B.* ; Hernesniemi, J.* ; Lindgren, C.M.* ; Wong, J.A.* ; Huang, J.* ; Eskola, M.* ; Morris, A.P.* ; Ford, I.* ; Reiner, A.P.* ; Delgado, G.* ; Chen, L.Y.* ; Chen, Y.I.* ; Sandhu, R.K.* ; Boerwinkle, E.* ; Eisele, L.* ; Lannfelt, L.* ; Rost, N.* ; Anderson, C.D.* ; Taylor, K.D.* ; Campbell, A.* ; Magnusson, P.K.* ; Porteous, D.J.* ; Hocking, L.J.* ; Vlachopoulou, E.* ; Pedersen, N.L.* ; Nikus, K.* ; Orho-Melander, M.* ; Hamsten, A.* ; Heeringa, J.* ; Denny, J.C.* ; Kriebel, J. ; Darbar, D.* ; Newton-Cheh, C.* ; Shaffer, C.* ; Macfarlane, P.W.* ; Heilmann-Heimbach, S.* ; Almgren, P.* ; Huang, P.L.* ; Sotoodehnia, N.* ; Soliman, E.Z.* ; Uitterlinden, A.G.* ; Hofman, A.* ; Franco, O.H.* ; Voelker, U.* ; Joeckel, K.* ; Sinner, M.F.* ; Lin, H.J.* ; Guo, X.* ; Dichgans, M.* ; Ingelsson, E.* ; Kooperberg, C.* ; Melander, O.* ; Loos, R.J.F.* ; Laurikka, J.* ; Conen, D.* ; Rosand, J.* ; van der Harst, P.* ; Lokki, M.L.* ; Kathiresan, S.* ; Pereira, A.C.* ; Jukema, J.W.* ; Hayward, C.* ; Rotter, J.I.* ; Maerz, W.* ; Lehtimäki, T.* ; Stricker, B.H.* ; Chung, M.K.* ; Felix, S.B.* ; Gudnason, V.* ; Alonso, A.* ; Roden, D.M.* ; Kaeaeb, S.* ; Chasman, D.I.* ; Heckbert, S.R.* ; Benjamin, E.J.* ; Tanaka, T.* ; Lunetta, K.L.* ; Lubitz, S.A.* ; Ellinor, P.T.*

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.

Nat. Genet. 49, 946-952 (2017)
Postprint DOI PMC
Open Access Green
Atrial fibrillation affects more than 33 million people worldwide and increases the risk of stroke, heart failure, and death(1,2). Fourteen genetic loci have been associated with atrial fibrillation in European and Asian ancestry groups(3-7). To further define the genetic basis of atrial fibrillation, we performed large-scale, trans-ancestry meta-analyses of common and rare variant association studies. The genome-wide association studies (GWAS) included 17,931 individuals with atrial fibrillation and 115,142 referents; the exome-wide association studies (ExWAS) and rare variant association studies (RVAS) involved 22,346 cases and 132,086 referents. We identified 12 new genetic loci that exceeded genome-wide significance, implicating genes involved in cardiac electrical and structural remodeling. Our results nearly double the number of known genetic loci for atrial fibrillation, provide insights into the molecular basis of atrial fibrillation, and may facilitate the identification of new potential targets for drug discovery(8).
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
27.959
6.620
135
168
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Genome-wide Association; Genetic-variation; Risk; Annotation; Burden; Tool; Snp; Susceptibility; Visualization; Metaanalysis
Language english
Publication Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 49, Issue: 6, Pages: 946-952 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology (EPI)
CF Genomics (CF-GEN)
Institute of Human Genetics (IHG)
POF-Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504100-001
G-504090-001
G-504091-001
A-632700-001
G-504000-010
G-504091-002
G-500700-001
G-504000-001
DOI 10.1038/ng.3843
WOS ID WOS:000402062300020
Scopus ID 85017510399
PubMed ID 28416818
Erfassungsdatum 2017-07-03
[➜Report correction]