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Karp, N.A.* ; Mason, J.* ; Beaudet, A.L.* ; Benjamini, Y.* ; Bower, L.* ; Braun, R.E.* ; Brown, S.D.M.* ; Chesler, E.J.* ; Dickinson, M.E.* ; Flenniken, A.M.* ; Fuchs, H. ; Hrabě de Angelis, M. ; Gao, X.* ; Guo, S.* ; Greenaway, S.* ; Heller, R.* ; Herault, Y.* ; Justice, M.J.* ; Kurbatova, N.* ; Lelliott, C.J.* ; Lloyd, K.C.K.* ; Mallon, A.M.* ; Mank, J.E.* ; Masuya, H.* ; McKerlie, C.* ; Meehan, T.F.* ; Mott, R.F.* ; Murray, S.A.* ; Parkinson, H.* ; Ramirez-Solis, R.* ; Santos, L.* ; Seavitt, J.R.* ; Smedley, D.* ; Sorg, T.* ; Speak, A.O.* ; Steel, K.P.* ; Svenson, K.L.* ; Wakana, S.* ; West, D.* ; Wells, S.* ; Westerberg, H.* ; Yaacoby, S.* ; White, J.K.* ; International Mouse Phenotyping Consortium (Aguilar-Pimentel, J.A. ; Treise, I. ; Moreth, K. ; Stöger, T. ; Amarie, O.V. ; Neff, C. ; Wurst, W. ; Calzada-Wack, J. ; Marschall, S. ; Brommage, R. ; Steinkamp, R. ; Lengger, C. ; Östereicher, M.A. ; Maier, H. ; Stoeger, C. ; Leuchtenberger, S. ; Yildirim, A.Ö. ; Garrett, L. ; Hölter, S.M. ; Zimprich, A. ; Seisenberger, C. ; Bürger, A. ; Graw, J. ; Eickelberg, O. ; Schmidt-Weber, C.B. ; Gailus-Durner, V. ; Beckers, J. ; Rathkolb, B. ; Rozman, J.) ; Becker, L.

Prevalence of sexual dimorphism in mammalian phenotypic traits.

Nat. Commun. 8:15475 (2017)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Gene-function; Biomedical-research; Consortium; Expression; Science; Mice; Bias
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 8, Issue: , Pages: , Article Number: 15475 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
Lung Health and Immunity (LHI)