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Direct neuronal reprogramming: Achievements, hurdles, and new roads to success.
Cell Stem Cell 21, 18-34 (2017)
Publ. Version/Full Text
DOI
PMC
The ability to directly reprogram mature cells to alternative fates challenges concepts of how cell identities are maintained, erased, and acquired. Recent advances in understanding and overcoming hurdles to direct neuronal conversion have provided new insights into mechanisms that maintain cell identity programs and have enabled high efficiency reprogramming in vivo. We discuss key cell-intrinsic molecular and metabolic constraints that influence the establishment of a new identity as well as environmental inputs from injured brains that favor or harm the conversion process. Finally, we outline the challenges ahead with a particular focus on direct neuronal reprogramming in vivo.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Brain Repair ; Conversion ; Direct Reprogramming ; Ipsc ; Metabolism ; Neurogenesis ; Neuron ; Stem Cells ; Transdifferentiation; Pluripotent Stem-cells; Traumatic Brain-injury; Microglia/macrophage Polarization Dynamics; Chromatin-remodeling Complexes; Neural Stem/progenitor Cells; Elegans Germ-cells; In-vivo; Direct Conversion; Functional-neurons; Human Fibroblasts
ISSN (print) / ISBN
1934-5909
e-ISSN
1875-9777
Journal
Cell Stem Cell
Quellenangaben
Volume: 21,
Issue: 1,
Pages: 18-34
Publisher
Cell Press
Publishing Place
Cambridge, Mass.
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)