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Karlas, A. ; Reber, J. ; Diot, G.* ; Bozhko, D. ; Anastasopoulou, M. ; Ibrahim, T.* ; Schwaiger, M.* ; Hyafil, F.* ; Ntziachristos, V.

Flow-mediated dilatation test using optoacoustic imaging: A proof-of-concept.

Biomed. Opt. Express 8, 3395-3403 (2017)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
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Label-free multispectral optoacoustic tomography (MSOT) has recently shown superior performance in visualizing the morphology of human vasculature, especially of smaller vessels, compared to ultrasonography. Herein, we extend these observations towards MSOT interrogation of macrovascular endothelial function. We employed a real-time handheld MSOT scanner to assess flow-mediated dilatation (FMD), a technique used to characterize endothelial function. A data processing scheme was developed to quantify the dimensions and diameter changes of arteries in humans and determine wall distensibility parameters. By enabling high-resolution delineation of the blood-vessel wall in a cross-sectional fashion, the findings suggest MSOT as a capable alternative to ultrasonography for clinical FMD measurements.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords (000.1430) Biology And Medicine ; (110.5120) Photoacoustic Imaging ; (110.5125) Photoacoustics ; (170.3880) Medical And Biological Imaging ; (170.5380) Physiology; Brachial-artery; Vasodilation; Risk
ISSN (print) / ISBN 2156-7085
e-ISSN 2156-7085
Quellenangaben Volume: 8, Issue: 7, Pages: 3395-3403 Article Number: , Supplement: ,
Publisher Optical Society of America (OSA)
Publishing Place Washington
Non-patent literature Publications
Reviewing status Peer reviewed