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Karlas, A. ; Reber, J. ; Diot, G.* ; Bozhko, D. ; Anastasopoulou, M. ; Ibrahim, T.* ; Schwaiger, M.* ; Hyafil, F.* ; Ntziachristos, V.

Flow-mediated dilatation test using optoacoustic imaging: A proof-of-concept.

Biomed. Opt. Express 8, 3395-3403 (2017)
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Label-free multispectral optoacoustic tomography (MSOT) has recently shown superior performance in visualizing the morphology of human vasculature, especially of smaller vessels, compared to ultrasonography. Herein, we extend these observations towards MSOT interrogation of macrovascular endothelial function. We employed a real-time handheld MSOT scanner to assess flow-mediated dilatation (FMD), a technique used to characterize endothelial function. A data processing scheme was developed to quantify the dimensions and diameter changes of arteries in humans and determine wall distensibility parameters. By enabling high-resolution delineation of the blood-vessel wall in a cross-sectional fashion, the findings suggest MSOT as a capable alternative to ultrasonography for clinical FMD measurements.
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Publication type Article: Journal article
Document type Scientific Article
Keywords (000.1430) Biology And Medicine ; (110.5120) Photoacoustic Imaging ; (110.5125) Photoacoustics ; (170.3880) Medical And Biological Imaging ; (170.5380) Physiology; Brachial-artery; Vasodilation; Risk
Language english
Publication Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 2156-7085
e-ISSN 2156-7085
Journal Biomedical Optics Express
Quellenangaben Volume: 8, Issue: 7, Pages: 3395-3403 Article Number: , Supplement: ,
Publisher Optical Society of America (OSA)
Publishing Place Washington
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505500-001
PubMed ID 28717575
DOI 10.1364/BOE.8.003395
WOS ID WOS:000404738300018
Scopus ID 85023636665
Erfassungsdatum 2017-07-24
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