PuSH - Publication Server of Helmholtz Zentrum München: Dissociation between brown adipose tissue<sup> 18</sup>F-FDG uptake and thermogenesis in uncoupling protein 1 deficient mice.

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Hankir, M.K.* ; Kranz, M.* ; Keipert, S. ; Weiner, J.* ; Andreasen, S.G.* ; Kern, M.J.* ; Patt, M.* ; Kloeting, N.* ; Heiker, J.T.* ; Brust, P.* ; Hesse, S.* ; Jastroch, M. ; Fenske, W.K.*

Dissociation between brown adipose tissue¹⁸F-FDG uptake and thermogenesis in uncoupling protein 1 deficient mice.

J. Nucl. Med. 58, 1100-1103 (2017)

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F-18-FDG PET imaging is routinely used to investigate brown adipose tissue (BAT) thermogenesis, which requires mitochondrial uncoupling protein 1 (UCP1). It remains uncertain, however, whether BAT F-18-FDG uptake is a reliable surrogate measure of UCP1-mediated heat production. Methods: UCP1 knockout (KO) and wild-type (WT) mice housed at thermoneutrality were treated with the selective beta 3 adrenergic receptor agonist CL 316, 243 and under-went metabolic cage, infrared thermal imaging and F-18-FDG PET/MRI experiments. Primary brown adipocytes were additionally examined for their bioenergetics by extracellular flux analysis as well as their uptake of 2-deoxy-H-3-glucose. Results: In response to CL 316, 243 treatments, oxygen consumption, and BAT thermogenesis were diminished in UCP1 KO mice, but BAT F-18-FDG uptake was fully retained. Isolated UCP1 KO brown adipocytes exhibited defective induction of uncoupled respiration whereas their glycolytic flux and 2-deoxy-H-3-glucose uptake rates were largely unaffected. Conclusion: Adrenergic stimulation can increase BAT F-18-FDG uptake independently of UCP1 thermogenic function.

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PuSH - Publication Server of Helmholtz Zentrum München

Dissociation between brown adipose tissue 18F-FDG uptake and thermogenesis in uncoupling protein 1 deficient mice.

Dissociation between brown adipose tissue¹⁸F-FDG uptake and thermogenesis in uncoupling protein 1 deficient mice.