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Shevtsov, M.* ; Zhao, L. ; Protzer, U. ; Klundert, M.A.A.

Applicability of metal nanoparticles in the detection and monitoring of hepatitis B virus infection.

Viruses 9:193 (2017)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Chronic infection with the hepatitis B virus (HBV) can lead to liver failure and can cause liver cirrhosis and hepatocellular carcinoma (HCC). Reliable means for detecting and monitoring HBV infection are essential to identify patients in need of therapy and to prevent HBV transmission. Nanomaterials with defined electrical, optical, and mechanical properties have been developed to detect and quantify viral antigens. In this review, we discuss the challenges in applying nanoparticles to HBV antigen detection and in realizing the bio-analytical potential of such nanoparticles. We discuss recent developments in generating detection platforms based on gold and iron oxide nanoparticles. Such platforms increase biological material detection efficiency by the targeted capture and concentration of HBV antigens, but the unique properties of nanoparticles can also be exploited for direct, sensitive, and specific antigen detection. We discuss several studies that show that nanomaterial-based platforms enable ultrasensitive HBV antigen detection.
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Publication type Article: Journal article
Document type Review
Keywords Biosensor ; Gold Nanoparticles ; Hepatitis B ; Magnetic Nanoparticles ; Virus; Surface-plasmon Resonance; Iron-oxide Nanoparticles; Lateral Flow Strips; Gold Nanoparticles; Magnetic Nanoparticles; Quantum Dots; Ultrasensitive Detection; C Virus; Superparamagnetic Nanoparticles; Electrochemical Biosensors
Language english
Publication Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 1999-4915
e-ISSN 1999-4915
Journal Viruses
Quellenangaben Volume: 9, Issue: 7, Pages: , Article Number: 193 Supplement: ,
Publisher MDPI
Publishing Place Basel
Reviewing status Peer reviewed
Institute(s) Institute of Virology (VIRO)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Immune Response and Infection
PSP Element(s) G-502700-003
PubMed ID 28753992
DOI 10.3390/v9070193
WOS ID WOS:000406684400035
Scopus ID 85026487869
Erfassungsdatum 2017-08-03
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