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Applicability of metal nanoparticles in the detection and monitoring of hepatitis B virus infection.
Viruses 9:193 (2017)
Chronic infection with the hepatitis B virus (HBV) can lead to liver failure and can cause liver cirrhosis and hepatocellular carcinoma (HCC). Reliable means for detecting and monitoring HBV infection are essential to identify patients in need of therapy and to prevent HBV transmission. Nanomaterials with defined electrical, optical, and mechanical properties have been developed to detect and quantify viral antigens. In this review, we discuss the challenges in applying nanoparticles to HBV antigen detection and in realizing the bio-analytical potential of such nanoparticles. We discuss recent developments in generating detection platforms based on gold and iron oxide nanoparticles. Such platforms increase biological material detection efficiency by the targeted capture and concentration of HBV antigens, but the unique properties of nanoparticles can also be exploited for direct, sensitive, and specific antigen detection. We discuss several studies that show that nanomaterial-based platforms enable ultrasensitive HBV antigen detection.
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Publication type
Article: Journal article
Document type
Review
Keywords
Biosensor ; Gold Nanoparticles ; Hepatitis B ; Magnetic Nanoparticles ; Virus; Surface-plasmon Resonance; Iron-oxide Nanoparticles; Lateral Flow Strips; Gold Nanoparticles; Magnetic Nanoparticles; Quantum Dots; Ultrasensitive Detection; C Virus; Superparamagnetic Nanoparticles; Electrochemical Biosensors
ISSN (print) / ISBN
1999-4915
e-ISSN
1999-4915
Journal
Viruses
Quellenangaben
Volume: 9,
Issue: 7,
Article Number: 193
Publisher
MDPI
Publishing Place
Basel
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Virology (VIRO)