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Stefan, N. ; Schick, F. ; Häring, H.-U.

Causes, characteristics, and consequences of metabolically unhealthy normal weight in humans.

Cell Metab. 26, 292-300 (2017)
Publ. Version/Full Text Research data DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
A BMI in the normal range associates with a decreased risk of cardiometabolic disease and all-cause mortality. However, not all subjects in this BMI range have this low risk. Compared to people who are of normal weight and metabolically healthy, subjects who are of normal weight but metabolically unhealthy (∼20% of the normal weight adult population) have a greater than 3-fold higher risk of all-cause mortality and/or cardiovascular events. Here we address to what extent major risk phenotypes determine metabolic health in lean compared to overweight and obese people and provide support for the existence of a lipodystrophy-like phenotype in the general population. Furthermore, we highlight the molecular mechanisms that induce this phenotype. Finally, we propose strategies as to how this knowledge could be implemented in the prevention and treatment of cardiometabolic diseases in different stages of adiposity in routine clinical practice.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cardiometabolic Diseases ; Insulin Resistance ; Insulin Secretion ; Leg Fat Mass ; Lipodystrophy-like Phenotype ; Metabolic Syndrome ; Metabolically Healthy Obesity ; Metabolically Unhealthy Normal Weight ; Nonalcoholic Fatty Liver Disease ; Visceral Obesity; metabolically unhealthy normal weight; metabolically healthy obesity; metabolic syndrome; nonalcoholic fatty liver disease; visceral obesity; leg fat mass; lipodystrophy-like phenotype; cardiometabolic diseases; insulin secretion; insulin resistance
Language english
Publication Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 1550-4131
e-ISSN 1932-7420
Journal Cell Metabolism
Quellenangaben Volume: 26, Issue: 2, Pages: 292-300 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502400-002
DOI 10.1016/j.cmet.2017.07.008
WOS ID WOS:000406681000007
Scopus ID 85030675839
PubMed ID 28768170
Erfassungsdatum 2017-08-04
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