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Flisikowska, T.* ; Stachowiak, M.* ; Xu, H.* ; Wagner, A.* ; Hernandez-Caceres, A.* ; Wurmser, C.* ; Perleberg, C.* ; Pausch, H.* ; Perkowska, A.* ; Fischer, K.* ; Frishman, D. ; Fries, R.* ; Switonski, M.* ; Kind, A.* ; Saur, D.* ; Schnieke, A.* ; Flisikowski, K.*

Porcine familial adenomatous polyposis model enables systematic analysis of early events in adenoma progression.

Sci. Rep. 7:6613 (2017)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
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We compared gene expression in low and high-grade intraepithelial dysplastic polyps from pigs carrying an APC 1311 truncating mutation orthologous to human APC 1309 , analysing whole samples and microdissected dysplastic epithelium. Gene set enrichment analysis revealed differential expression of gene sets similar to human normal mucosa versus T1 stage polyps. Transcriptome analysis of whole samples revealed many differentially-expressed genes reflecting immune infiltration. Analysis of microdissected dysplastic epithelium was markedly different and showed increased expression in high-grade intraepithelial neoplasia of several genes known to be involved in human CRC; and revealed possible new roles for GBP6 and PLXND1. The pig model thus facilitates analysis of CRC pathogenesis.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Set Enrichment Analysis; Dna-sequencing Data; Colorectal-cancer; Tumor-suppressor; Expression; Cells; Framework; Pathway; Genes; D1
Language english
Publication Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Journal Scientific Reports
Quellenangaben Volume: 7, Issue: 1, Pages: , Article Number: 6613 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Bioinformatics and Systems Biology (IBIS)
POF-Topic(s) 30505 - New Technologies for Biomedical Discoveries
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-503700-001
PubMed ID 28747659
DOI 10.1038/s41598-017-06741-8
WOS ID WOS:000406366400021
Scopus ID 85026368704
Erfassungsdatum 2017-09-08
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