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No evidence of association of FLJ10986 and ITPR2 with ALS in a large German cohort.
Neurobiol. Aging 32, 551.e1-551.e4 (2011)
A recent genome-wide association study (GWAS) found significant association of six single nucleotide polymorphisms (SNPs) in the gene FLJ10986 with sporadic amyotrophic lateral sclerosis (SALS). Another independent GWAS reported significant association of one SNP in the gene inositol 1,4,5-triphosphate receptor 2 (ITPR2) with SALS. These studies provided conflicting results. We examined the six most significant SNPs in FLJ10986 and one SNP in ITPR2 in a large cohort consisting of 595 SALS cases and 681 controls ascertained from Germany. Our results did not provide evidence for the association of these SNPs with SALS, suggesting a possible population-specific effect for FLJ10986 and ITPR2 that do not modulate the risk for SALS in the German population.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Amyotrophic lateral sclerosis (ALS); Genome-wide association study (GWAS); Single nucleotide polymorphism (SNP)
Language
english
Publication Year
2011
HGF-reported in Year
2011
ISSN (print) / ISBN
0197-4580
e-ISSN
1558-1497
Journal
Neurobiology of Aging
Quellenangaben
Volume: 32,
Issue: 3,
Pages: 551.e1-551.e4
Publisher
Elsevier
Publishing Place
New York, NY [u.a.]
Reviewing status
Peer reviewed
Institute(s)
Research Unit Molecular Epidemiology (AME)
POF-Topic(s)
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-504200-003
PubMed ID
19464757
Scopus ID
79952901096
Erfassungsdatum
2011-01-01