PuSH - Publication Server of Helmholtz Zentrum München: When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Simpson, E.L.* ; Bruin-Weller, M.* ; Flohr, C.* ; Ardern-Jones, M.R.* ; Barbarot, S.* ; Deleuran, M.* ; Bieber, T.* ; Vestergaard, C.* ; Brown, S.J.* ; Cork, M.J.* ; Drucker, A.M.* ; Eichenfield, L.F.* ; Foelster-Holst, R.* ; Guttman-Yassky, E.* ; Nosbaum, A.* ; Reynolds, N.J.* ; Silverberg, J.I.* ; Schmitt, J.* ; Seyger, M.M.B.* ; Spuls, P.I.* ; Stalder, J.F.* ; Su, J.C.* ; Takaoka, R.* ; Traidl-Hoffmann, C. ; Thyssen, J.P.* ; van der Schaft, J.* ; Wollenberg, A.* ; Irvine, A.D.* ; Paller, A.S.*

When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council.

J. Am. Acad. Dermatol. 77, 623-633 (2017)

Publ. Version/Full Text

DOI

PMC

	Open Access Gold (Paid Option)

Abstract
Metrics
Extra information

BACKGROUND: Although most patients with atopic dermatitis (AD) are effectively managed with topical medication, a significant minority require systemic therapy. Guidelines for decision making about advancement to systemic therapy are lacking. OBJECTIVE: To guide those considering use of systemic therapy in AD and provide a framework for evaluation before making this therapeutic decision with the patient. METHODS: A subgroup of the International Eczema Council determined aspects to consider before prescribing systemic therapy. Topics were assigned to expert reviewers who performed a topic-specific literature review, referred to guidelines when available, and provided interpretation and expert opinion. RESULTS: We recommend a systematic and holistic approach to assess patients with severe signs and symptoms of AD and impact on quality of life before systemic therapy. Steps taken before commencing systemic therapy include considering alternate or concomitant diagnoses, avoiding trigger factors, optimizing topical therapy, ensuring adequate patient/caregiver education, treating coexistent infection, assessing the impact on quality of life, and considering phototherapy. LIMITATIONS: Our work is a consensus statement, not a systematic review. CONCLUSION: The decision to start systemic medication should include assessment of severity and quality of life while considering the individual's general health status, psychologic needs, and personal attitudes toward systemic therapies.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Atopic Dermatitis ; Azathioprine ; Biologic ; Consensus Statement ; Cyclosporine ; Eczema ; Methotrexate ; Quality Of Life ; Systemic Therapy; Quality-of-life; Delayed-type Hypersensitivity; Scorad Po-scorad; Clinical-practice; Fluticasone Propionate; Staphylococcus-aureus; Tacrolimus Ointment; Severity Score; Position Paper; Adult Patients

ISSN (print) / ISBN 0190-9622

e-ISSN 1097-6787

Journal Journal of the American Academy of Dermatology : JAAD

Quellenangaben Volume: 77, Issue: 4, Pages: 623-633

Publisher Elsevier

Publishing Place New York

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Environmental Medicine (IEM)