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Sauvetre, A. ; May, R.G.* ; Harpaintner, R. ; Poschenrieder, C.* ; Schröder, P.

Metabolism of carbamazepine in plant roots and endophytic rhizobacteria isolated from Phragmites australis.

J. Hazard. Mater. 342, 85-95 (2018)
Postprint DOI PMC
Open Access Green
Carbamazepine (CBZ) is a pharmaceutical frequently categorized as a recalcitrant pollutant in the aquatic environment. Endophytic bacteria previously isolated from reed plants have shown the ability to promote growth of their host and to contribute to CBZ metabolism. In this work, a horseradish (Armoracia rusticana) hairy root (HR) culture has been used as a plant model to study the interactions between roots and endophytic bacteria in response to CBZ exposure. HRs could remove up to 5% of the initial CBZ concentration when they were grown in spiked Murashige and Skoog (MS) medium. Higher removal rates were observed when HRs were inoculated with the endophytic bacteria Rhizobium radiobacter (21%) and Diaphorobacter nitroreducens (10%). Transformation products resulting from CBZ degradation were identified using liquid chromatography-ultra high-resolution quadrupole time of flight mass spectrometry (LC-UHR-QTOF-MS). CBZ metabolism could be divided in four pathways. Metabolites involving GSH conjugation and 2,3-dihydroxylation, as well as acridine related compounds are described in plants for the first time. This study presents strong evidence that xenobiotic metabolism and degradation pathways in plants can be modulated by the interaction with their endophytic community. Hence it points to plausible applications for the elimination of recalcitrant compounds such as CBZ from wastewater in CWs.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Acridine Pathway ; Endophytic Bacteria ; Glutathione Conjugate ; Hairy Roots ; Phytoremediation; Pharmaceutical Compound Carbamazepine; Waste-water Treatment; Emerging Organic Contaminants; Fungus Pleurotus-ostreatus; Personal Care Products; Phytoremediation; Transformation; Degradation; Pollutants; Removal
ISSN (print) / ISBN 0304-3894
e-ISSN 1873-3336
Journal Journal of Hazardous Materials
Quellenangaben Volume: 342, Issue: , Pages: 85-95 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Research Unit Comparative Microbiome Analysis (COMI)