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RAS oncogenes direct metastasis.
Mol. Cell. Oncol. 4:e1345711 (2017)
RAS genes are cardinal driver oncogenes frequently and differentially mutated across bodily tumors. Their tumorigenic potential has been mainly ascribed to autonomous promotion of tumor cell proliferation and survival. However, recent evidence shows that RAS oncogenes also function to define metastatic tropism. Interestingly, RAS-driven metastasis is mediated by distinct chemokine sets that signal to endothelial and myeloid cells.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Chemokines ; Kras ; Lung Metastasis ; Malignant Pleural Effusion ; Nras
e-ISSN
2372-3556
Journal
Molecular & Cellular Oncology
Quellenangaben
Volume: 4,
Issue: 5,
Article Number: e1345711
Publisher
Taylor & Francis
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Lung Health and Immunity (LHI)