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Spella, M.* ; Marazioti, A.* ; Arendt, K.A.M. ; Stathopoulos, G.T.

RAS oncogenes direct metastasis.

Mol. Cell. Oncol. 4:e1345711 (2017)
Postprint DOI PMC
Open Access Green
RAS genes are cardinal driver oncogenes frequently and differentially mutated across bodily tumors. Their tumorigenic potential has been mainly ascribed to autonomous promotion of tumor cell proliferation and survival. However, recent evidence shows that RAS oncogenes also function to define metastatic tropism. Interestingly, RAS-driven metastasis is mediated by distinct chemokine sets that signal to endothelial and myeloid cells.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Chemokines ; Kras ; Lung Metastasis ; Malignant Pleural Effusion ; Nras
Language
Publication Year 2017
HGF-reported in Year 2017
e-ISSN 2372-3556
Quellenangaben Volume: 4, Issue: 5, Pages: , Article Number: e1345711 Supplement: ,
Publisher Taylor & Francis
Reviewing status Peer reviewed
POF-Topic(s) 30202 - Environmental Health
Research field(s) Lung Research
PSP Element(s) G-501600-003
Scopus ID 85050772609
PubMed ID 29057308
Erfassungsdatum 2017-09-05