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Malekzadeh Najafabadi, J.* ; Prakash, J. ; Ntziachristos, V.

Nonlinear optoacoustic readings from diffusive media at near-infrared wavelengths.

J. Biophotonics 11:e201600310 (2018)
Postprint DOI PMC
Open Access Green
Optoacoustic (photoacoustic) imaging assumes that the detected signal varies linearly with laser energy. However, nonlinear intensity responses as a function of light fluence have been suggested in optoacoustic microscopy, that is, within the first millimeter of tissue. In this study, we explore the presence of nonlinearity deeper in tissue (similar to 4 mm), as it relates to optoacoustic mesoscopy, and investigate the fluence required to delineate a switch from linear to nonlinear behavior. Optoacoustic signal nonlinearity is studied for different materials, different wavelengths and as a function of changes in the scattering and absorption coefficient of the medium imaged. We observe fluence thresholds in the mJ/cm(2) range and preliminary find that different materials may exhibit different nonlinearity patterns. We discuss the implications of nonlinearity in relation to image accuracy and quantification in optoacoustic tomography.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Nonlinearity ; Optical Imaging ; Optical Parameters ; Optoacoustic (photoacoustic) Imaging; Microscopy; Mesoscopy
ISSN (print) / ISBN 1864-063X
e-ISSN 1864-0648
Journal Journal of Biophotonics
Quellenangaben Volume: 11, Issue: 1, Pages: , Article Number: e201600310 Supplement: ,
Publisher Wiley
Publishing Place Weinheim
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)