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Heilbronner, U.* ; Jain, G.* ; Kaurani, L.* ; Kondofersky, I. ; Budde, M.* ; Gade, K.* ; Kalman, J.* ; Adorjan, K.* ; Aldinger, F.* ; Anderson-Schmidt, H.* ; Müller, N.S. ; Theis, F.J. ; Falkai, P.* ; Fischer, A.* ; Schulze, T.G.*

The Role of micrornas in the course of servere mental disorders.

Eur. Neuropsychopharmacol. 27, 3, S456-S457 (2017)

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Open Access Green as soon as Postprint is submitted to ZB.

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Background Illnesses from the schizophrenia-to-bipolar spectrum have a highly variable course. Determinants of these different individual trajectories have been of particular interest to scholars during the past century. Beyond rudimentary understanding, however, different course types have been difficult to delineate in categorical disease phenotypes. We have therefore embarked upon a project in which we seek to delineate different course types in a large longitudinal sample of deeply phenotyped patients suffering from disorders of the schizophrenia-to-bipolar continuum. With respect to biology, a dysregulation of microRNAs, small non-coding RNA molecules that flexibly influence transcription, in mental disorders is increasingly recognized. To combine both of these novel approaches, we plan investigate the role of microRNAs in different course types identified using longitudinal cluster analysis. Methods Longitudinal clustering Participants were selected from an ongoing longitudinal, multi-site study (www.kfo241.de, www.PsyCourse.de). Patients with a DSM-IV diagnosis of the schizophrenia-to-bipolar spectrum were comprehensively phenotyped at four time-points over a period of 18 months. A set of longitudinally measured variables on current psychopathology, medication adherence, substance use, cognitive performance, level of psychosocial functioning and various questionnaires was analyzed using factor analysis for mixed data followed by longitudinal cluster analyses. This resulted in the identification of distinct subpopulations of patients, each being heterogeneous in terms of diagnostic composition. MicroRNA sequencing So far, we have compared four different methods to isolate blood borne small non-coding RNAs for RNA-sequencing. By this we were able to establish SOPs for the reliable analysis of circulating small non-coding RNAs in longitudinal cohorts. Results We will present results of our research project at the meeting. Discussion We will discuss our research project at the meeting.

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