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Open Access Green as soon as Postprint is submitted to ZB.
Catching new targets in metabolic disease with a zebrafish.
Curr. Opin. Pharmacol. 37, 41-50 (2017)
Traditionally, the development of novel therapeutics for metabolic diseases has relied mainly on high-throughput screening using biochemical or cell-based assays. While this approach represents a driving force in drug discovery, there is also a need to perform large-scale screens without disrupting inter-organ communication and tissue architecture, essential components for understanding the complexity of metabolic regulation and the identification of small molecules with appropriate biological activities in vivo. Hence, the zebrafish Danio rerio is gaining popularity in metabolic research and drug discovery, as this animal model allows screening of small molecules in the context of the whole-organism. Moreover, the zebrafish exhibits conserved function of the pancreas, liver and adipose tissue, which can be leveraged to identify novel targets in metabolic regulation, as well as to study the role of conserved genes associated with the risk of metabolic diseases in humans. Here we highlight recent advances in the identification of targets in metabolic regulation using the zebrafish as a model.
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Publication type
Article: Journal article
Document type
Review
Keywords
Beta-cell Mass; Body-fat Distribution; Genetic Screen; Adipose-tissue; Liver-disease; Glucose-homeostasis; Danio-rerio; In-vivo; Regeneration; Pancreas
ISSN (print) / ISBN
1471-4892
e-ISSN
1471-4973
Journal
Current opinion in pharmacology
Quellenangaben
Volume: 37,
Pages: 41-50
Publisher
Elsevier
Publishing Place
London
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Pancreatic Beta Cell Research (IPI)