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Real-time three-dimensional temperature mapping in photothermal therapy with optoacoustic tomography.
Proc. SPIE 10415:104150A (2017)
Publ. Version/Full Text
DOI
Ablation and photothermal therapy are widely employed medical protocols where the selective destruction of tissue is a necessity as in cancerous tissue removal or vascular and brain abnormalities. Tissue denaturation takes place when the temperature reaches a threshold value while the time of exposure determines the lesion size. Therefore, the spatio-temporal distribution of temperature plays a crucial role in the outcome of these clinical interventions. We demonstrate fast volumetric temperature mapping with optoacoustic tomography based on real-time optoacoustic readings from the treated region. The performance of the method was investigated in tissue-mimicking phantom experiments. The new ability to non-invasively measure temperature volumetrically in an entire treated region with high spatial and temporal resolutions holds potential for improving safety and efficacy of thermal ablation and to advance the general applicability of laser-based therapy.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Ablation Of Tissue ; Optoacoustic Imaging ; Optoacoustic Tomography ; Temperature
ISSN (print) / ISBN
0277-786X
e-ISSN
1996-756X
Conference Title
European Conferences on Biomedical Optics 2017
Conference Date
25-29 June 2017
Conference Location
Munich, Germany
Journal
Proceedings of SPIE
Quellenangaben
Volume: 10415,
Article Number: 104150A
Publisher
SPIE
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)