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The importance of speciation analysis in neurodegeneration research.
Trends Analyt. Chem. 104, 160-170 (2017)
Element speciation offers deeper insight into the molecular mechanisms of disease by determining element species pattern. Thus, having great potential for investigating neurodegeneration in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and mild cognitive impairment, speciation is increasingly considered in epidemiological or clinical neurological studies. This review analyses recent speciation findings in neurodegeneration research, concentrating on measurements in cerebrospinal fluid and brain. Elements considered are aluminum, arsenic, copper, iron, mercury, manganese, selenium and zinc. Also interactions of trace element species are discussed briefly. Typically, hyphenated techniques are used in neurodegeneration speciation studies. The results allow sorting-out less important species from compounds significant for the disease, with subsequent use of molecular biology methods to uncover the exact mechanisms. This review indicates the trend of combining speciation and neuroscience and provides a sketch about data and outcomes. For brain research, we recommend using modern, powerful techniques throughout which provide advanced validity and information in a chemical sense.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Speciation ; Neurodegeneration ; Cerebrospinal Fluid ; Brain ; Hyphenated Techniques ; Inductively Coupled Plasma Mass Spectrometry ; High Pressure Liquid Chromatography ; Trace Element ; Redox Stability ; Quality Control; Plasma-mass Spectrometry; Cerebrospinal-fluid Selenium; Lateral-sclerosis Patients; Alzheimers-disease; Selenoprotein-p; Parkinsons-disease; Isotope-dilution; Brain-tissue; Icp-ms; Chemical Speciation
Language
Publication Year
2017
HGF-reported in Year
2017
ISSN (print) / ISBN
0165-9936
e-ISSN
1873-3689
Quellenangaben
Volume: 104,
Pages: 160-170
Publisher
Elsevier
Publishing Place
The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England
Reviewing status
Peer reviewed
Institute(s)
Research Unit BioGeoChemistry and Analytics (BGC)
POF-Topic(s)
30202 - Environmental Health
Research field(s)
Environmental Sciences
PSP Element(s)
G-504800-002
WOS ID
WOS:000438004400015
Scopus ID
85028669730
Erfassungsdatum
2017-09-26