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Entenmann, L.* ; Pietzner, M.* ; Artati, A. ; Hannemann, A.* ; Henning, A.K.* ; Kastenmüller, G. ; Völzke, H.* ; Nauck, M.* ; Adamski, J. ; Wallaschofski, H.* ; Friedrich, N.*

Comprehensive metabolic characterization of serum osteocalcin action in a large non-diabetic sample.

PLoS ONE 12:e0184721 (2017)

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Recent research suggested a metabolic implication of osteocalcin (OCN) in e.g. insulin sensitivity or steroid production. We used an untargeted metabolomics approach by analyzing plasma and urine samples of 931 participants using mass spectrometry to reveal further metabolic actions of OCN. Several detected relations between OCN and metabolites were strongly linked to renal function, however, a number of associations remained significant after adjustment for renal function. Intermediates of proline catabolism were associated with OCN reflecting the implication in bone metabolism. The association to kynurenine points towards a pro-inflammatory state with increasing OCN. Inverse relations with intermediates of branch-chained amino acid metabolism suggest a link to energy metabolism. Finally, urinary surrogate markers of smoking highlight its adverse effect on OCN metabolism. In conclusion, the present study provides a read-out of metabolic actions of OCN. However, most of the associations were weak arguing for a limited role of OCN in whole-body metabolism.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Nitric-oxide Synthase; Osteoblast-like Cells; Bone-mineral Density; General-population; Functional-role; Insulin; Expression; Fracture; Receptor; Mass

ISSN (print) / ISBN 1932-6203

Journal PLoS ONE

Quellenangaben Volume: 12, Issue: 9, Article Number: e0184721

Publisher Public Library of Science (PLoS)

Publishing Place Lawrence, Kan.

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Bioinformatics and Systems Biology (IBIS)
Molekulare Endokrinologie und Metabolismus (MEM)