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MSX1-induced neural crest-like reprogramming promotes melanoma progression.
J. Invest. Dermatol. 138, 141-149 (2018)
Melanoma cells share many biological properties with neural crest stem cells. Here we show that the homeodomain transcription factor Msh homeobox 1 (MSX1), which is significantly correlated with melanoma disease progression, reprograms melanocytes and melanoma cells towards a neural crest precursor-like state. MSX1-reprogrammed normal human melanocytes express the neural crest marker p75 and become multipotent. MSX1 induces a phenotypic switch in melanoma, which is characterized by an oncogenic transition from an E-cadherin-high non-migratory state towards a ZEB1-high invasive state. ZEB1 up-regulation is responsible for the MSX1-induced migratory phenotype in melanoma cells. Depletion of MSX1 significantly inhibits melanoma metastasis in vivo. These results demonstrate that neural crest-like reprogramming achieved by a single factor is a critical process for melanoma progression.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Mesenchymal Stem-cells; Transcription Factor; Liver-diseases; Expression; Cancer; Microphthalmia; Melanocytes; Phenotype; Gene; Msx1
ISSN (print) / ISBN
0022-202X
e-ISSN
1523-1747
Quellenangaben
Volume: 138,
Issue: 1,
Pages: 141-149
Publisher
Elsevier
Publishing Place
New York, NY
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Experimental Genetics (IEG)