PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Einer, C. ; Hohenester, S.* ; Wimmer, R.* ; Wottke, L.* ; Artmann, R.* ; Schulz, S. ; Gosmann, C. ; Simmons, A. ; Leitzinger, C. ; Eberhagen, C. ; Borchard, S. ; Schmitt, S.* ; Hauck, S.M. ; von Toerne, C. ; Jastroch, M. ; Walheim, E. ; Rust, C.* ; Gerbes, A.L.* ; Popper, B.* ; Mayr, D.* ; Schnurr, M.* ; Vollmar, A.M.* ; Denk, G.U.* ; Zischka, H.

Mitochondrial adaptation in steatotic mice.

Mitochondrion, DOI: 10.1016/j.mito.2017.08.015 (2018)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Western lifestyle-associated malnutrition causes steatosis that may progress to liver inflammation and mitochondrial dysfunction has been suggested as a key factor in promoting this disease. Here we have molecularly, biochemically and biophysically analyzed mitochondria from steatotic wild type and immune-compromised mice fed a Western diet (WD) - enriched in saturated fatty acids (SFAs). WD-mitochondria demonstrated lipidomic changes, a decreased mitochondrial ATP production capacity and a significant sensitivity to calcium. These changes preceded hepatocyte damage and were not associated with enhanced ROS production. Thus, WD-mitochondria do not promote steatohepatitis per se, but demonstrate bioenergetic deficits and increased sensitivity to stress signals.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
3.226
0.977
1
41
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Mitochondria ; Nafld ; Steatosis ; Western Diet
Language english
Publication Year 2018
Prepublished in Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 1567-7249
e-ISSN 1872-8278
Journal Mitochondrion
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Molecular Toxicology and Pharmacology (TOX)
CF Metabolomics & Proteomics (CF-MPC)
Institute of Diabetes and Obesity (IDO)
POF-Topic(s) 30203 - Molecular Targets and Therapies
30201 - Metabolic Health
90000 - German Center for Diabetes Research
Research field(s) Enabling and Novel Technologies
Helmholtz Diabetes Center
PSP Element(s) G-505200-003
G-505700-001
G-502200-001
G-501900-221
DOI 10.1016/j.mito.2017.08.015
Scopus ID 85030089564
PubMed ID 28935446
Erfassungsdatum 2017-09-28
[➜Report correction]