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Einer, C. ; Hohenester, S.* ; Wimmer, R.* ; Wottke, L.* ; Artmann, R.* ; Schulz, S. ; Gosmann, C. ; Simmons, A. ; Leitzinger, C. ; Eberhagen, C. ; Borchard, S. ; Schmitt, S.* ; Hauck, S.M. ; von Toerne, C. ; Jastroch, M. ; Walheim, E. ; Rust, C.* ; Gerbes, A.L.* ; Popper, B.* ; Mayr, D.* ; Schnurr, M.* ; Vollmar, A.M.* ; Denk, G.U.* ; Zischka, H.

Mitochondrial adaptation in steatotic mice.

Mitochondrion, DOI: 10.1016/j.mito.2017.08.015 (2018)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Western lifestyle-associated malnutrition causes steatosis that may progress to liver inflammation and mitochondrial dysfunction has been suggested as a key factor in promoting this disease. Here we have molecularly, biochemically and biophysically analyzed mitochondria from steatotic wild type and immune-compromised mice fed a Western diet (WD) - enriched in saturated fatty acids (SFAs). WD-mitochondria demonstrated lipidomic changes, a decreased mitochondrial ATP production capacity and a significant sensitivity to calcium. These changes preceded hepatocyte damage and were not associated with enhanced ROS production. Thus, WD-mitochondria do not promote steatohepatitis per se, but demonstrate bioenergetic deficits and increased sensitivity to stress signals.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Mitochondria ; Nafld ; Steatosis ; Western Diet
ISSN (print) / ISBN 1567-7249
e-ISSN 1872-8278
Journal Mitochondrion
Publisher Elsevier
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Molecular Toxicology and Pharmacology (TOXI)
CF Metabolomics & Proteomics (CF-MPC)
Institute of Diabetes and Obesity (IDO)