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Mass spectrometry-based phytochemical screening for hypoglycemic activity of Fagioli di Sarconi beans (Phaseolus vulgaris L.).
Food Chem. 242, 497-504 (2017)
The present study deals with the evaluation of antidiabetic activities of Fagioli di Sarconi beans (Phaseolus vulgaris), including 21 ecotypes protected by the European Union with the mark PGI (i.e., Protected Geographical Indication), and cultivated in Basilicata (southern Italy). For this purpose, α-glucosidase and α-amylase assays were assessed; among all bean ecotypes, the tight green seed colour of Verdolino extracts exhibited the highest α-glucosidase and α-amylase inhibitory activity with IC50 = 1.1 ± 0.1 μg/ml and IC50 = 19.3 ± 1.1 μg/ml, respectively. Phytochemical compound screening of all Fagioli di Sarconi beans performed by flow injection-electrospray ionization-ultrahigh resolution mass spectrometry (uHRMS) and based on the calculation of elemental formulas from accurate m/z values, was helpful to annotate specific compounds, such as alkaloids, saponins, flavonoids, and terpenoids, which are most likely responsible for their biological activity.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Fagioli di Sarconi beans; Phaseouls vulgaris L.; High-resolution mass spectrometry; Phytochemical profile; Antidiabetic activity; α-Glucosidase; α-Amylase; Type-2 Diabetes-mellitus; Alpha-amylase; Organic-matter; Glucosidase; Legumes; Antioxidant; Inhibitors; Pathways; Saponins; Acarbose
Language
Publication Year
2017
HGF-reported in Year
2017
ISSN (print) / ISBN
0308-8146
e-ISSN
1873-7072
Journal
Food Chemistry
Quellenangaben
Volume: 242,
Pages: 497-504
Publisher
Elsevier
Publishing Place
Amsterdam [u.a.] ; Jena
Reviewing status
Peer reviewed
Institute(s)
Research Unit BioGeoChemistry and Analytics (BGC)
POF-Topic(s)
30202 - Environmental Health
Research field(s)
Environmental Sciences
PSP Element(s)
G-504800-001
WOS ID
WOS:000413291700065
Scopus ID
85029807318
PubMed ID
29037720
Erfassungsdatum
2017-09-27