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Kaloff, C. ; Anastassiadis, K.* ; Ayadi, A.* ; Baldock, R.* ; Beig, J. ; Birling, M.C.* ; Bradley, A.* ; Brown, S.D.M.* ; Bürger, A. ; Bushell, W.* ; Chiani, F.* ; Collins, F.S.* ; Doe, B.* ; Eppig, J.T.* ; Finnell, R.H.* ; Fletcher, C.* ; Flicek, P.* ; Fray, M.* ; Friedel, R.H.* ; Gambadoro, A.* ; Gates, H.* ; Hansen, J. ; Herault, Y.* ; Hicks, G.G.* ; Hörlein, A. ; Hrabě de Angelis, M. ; Iyer, V.* ; de Jong, P.J.* ; Koscielny, G.* ; Kühn, R. ; Liu, P.* ; Lloyd, K.C.K.* ; Lopez, R.G.* ; Marschall, S. ; Martínez, S.* ; McKerlie, C.* ; Meehan, T.F.* ; von Melchner, H.* ; Moore, M.* ; Murray, S.A.* ; Nagy, A.* ; Nutter, L.M.J.* ; Pavlovic, G.* ; Pombero, A.* ; Prosser, H.* ; Ramirez-Solis, R.* ; Ringwald, M.* ; Rosen, B.* ; Rosenthal, N.* ; Rossant, J.* ; Ruiz Noppinger, P.* ; Ryder, E.* ; Skarnes, W.C.* ; Schick, J. ; Schnütgen, F.* ; Schofield, P.* ; Seisenberger, C. ; Selloum, M.* ; Smedley, D.* ; Simpson, E.M.* ; Stewart, A.F.* ; Teboul, L.* ; Tocchini Valentini, G.P.* ; Valenzuela, D.* ; West, A.P.* ; Wurst, W.

Genome wide conditional mouse knockout resources.

Drug Discov. Today, DOI: 10.1016/j.ddmod.2017.08.002 (2017)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
© 2017 Elsevier Ltd. The International Knockout Mouse Consortium (IKMC) developed high throughput gene trapping and gene targeting pipelines that produced mostly conditional mutations of more than 18,500 genes in C57BL/6N mouse embryonic stem (ES) cells which have been archived and are freely available to the research community as a frozen resource. From this unprecedented resource more than 6000 mutant mouse strains have been generated by the IKMC in collaboration with the International Mouse Phenotyping Consortium (IMPC). In addition, a cre-driver resource was established including 250 C57BL/6 cre-inducible mouse strains. Complementing the cre-driver resource, a collection comprising 27 rAAVs expressing cre in a tissue-specific manner has also been produced. All resources are easily accessible from the IKMC/IMPC web portal (www.mousephenotype.org). The IKMC/IMPC resource is a standardized reference library of mouse models with defined genetic backgrounds enabling the analysis of gene-disease associations in mice of different genetic makeup and should therefore have a major impact on biomedical research.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 1359-6446
e-ISSN 1878-5832
Journal Drug discovery today
Publisher Elsevier
Publishing Place Cambridge
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)
Institute of Experimental Genetics (IEG)
Institute of Molecular Toxicology and Pharmacology (TOX)
POF-Topic(s) 30204 - Cell Programming and Repair
30201 - Metabolic Health
30203 - Molecular Targets and Therapies
Research field(s) Genetics and Epidemiology
Enabling and Novel Technologies
PSP Element(s) G-500500-001
G-500600-001
G-500692-001
G-505200-001
DOI 10.1016/j.ddmod.2017.08.002
Scopus ID 85029227398
Erfassungsdatum 2017-09-28
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