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Systems medicine advances in interstitial lung disease.
Eur. Respir. Rev. 26:170021 (2017)
Fibrotic lung diseases involve subject-environment interactions, together with dysregulated homeostatic processes, impaired DNA repair and distorted immune functions. Systems medicine-based approaches are used to analyse diseases in a holistic manner, by integrating systems biology platforms along with clinical parameters, for the purpose of understanding disease origin, progression, exacerbation and remission.Interstitial lung diseases (ILDs) refer to a heterogeneous group of complex fibrotic diseases. The increase of systems medicine-based approaches in the understanding of ILDs provides exceptional advantages by improving diagnostics, unravelling phenotypical differences, and stratifying patient populations by predictable outcomes and personalised treatments. This review discusses the state-of-the-art contributions of systems medicine-based approaches in ILDs over the past 5 years.
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Publication type
Article: Journal article
Document type
Review
ISSN (print) / ISBN
0905-9180
e-ISSN
1600-0617
Journal
European Respiratory Review
Quellenangaben
Volume: 26,
Issue: 145,
Article Number: 170021
Publisher
European Respiratory Society
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Lung Health and Immunity (LHI)