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Keller, T.* ; Hohmann, C.* ; Standl, M. ; Wijga, A.H.* ; Gehring, U.* ; Melén, E.* ; Almqvist, C.* ; Lau, S.* ; Eller, E.* ; Wahn, U.* ; Christiansen, E.S.* ; V Berg, A.* ; Heinrich, J. ; Lehmann, I.* ; Maier, D.* ; Postma, D.S.* ; Antò, J.M.* ; Bousquet, J.* ; Keil, T.* ; Roll, S.*

The sex-shift in single disease and multimorbid asthma and rhinitis during puberty - a study by MeDALL.

Allergy 73, 602-614 (2018)
Publ. Version/Full Text Postprint Research data DOI PMC
Open Access Hybrid
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BackgroundCross-sectional studies suggested that allergy prevalence in childhood is higher in boys compared to girls, but it remains unclear whether this inequality changes after puberty. We examined the sex-specific prevalence of asthma and rhinitis as single and as multimorbid diseases before and after puberty onset in longitudinal cohort data. MethodsIn six European population-based birth cohorts of MeDALL, we assessed the outcomes: current rhinitis, current asthma, current allergic multimorbidity (ie, concurrent asthma and rhinitis), puberty status and allergic sensitization by specific serum antibodies (immunoglobulin E) against aero-allergens. With generalized estimating equations, we analysed the effects of sex, age, puberty (yes/no) and possible confounders on the prevalence of asthma and rhinitis, and allergic multimorbidity in each cohort separately and performed individual participant data meta-analysis. FindingsWe included data from 19013 participants from birth to age 14-20years. Current rhinitis only affected girls less often than boys before and after puberty onset: adjusted odds ratio for females vs males 0.79 (95%-confidence interval 0.73-0.86) and 0.86 (0.79-0.94), respectively (sex-puberty interaction P=.089). Similarly, for current asthma only, females were less often affected than boys both before and after puberty onset: 0.71, 0.63-0.81 and 0.81, 0.64-1.02, respectively (sex-puberty interaction P=.327). The prevalence of allergic multimorbidity showed the strongest sex effect before puberty onset (female-male-OR 0.55, 0.46-0.64) and a considerable shift towards a sex-balanced prevalence after puberty onset (0.89, 0.74-1.04); sex-puberty interaction: P<.001. InterpretationThe male predominance in prevalence before puberty and the sex-shift towards females after puberty onset were strongest in multimorbid patients who had asthma and rhinitis concurrently.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Allergic Multimorbidity ; Asthma ; Birth Cohort ; Puberty ; Rhinitis; Birth Cohort; Allergic Diseases; Childhood Isaac; Gender-differences; Natural-history; Children; Prevalence; Eczema; Adolescence; Age
Language english
Publication Year 2018
Prepublished in Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Journal Allergy
Quellenangaben Volume: 73, Issue: 3, Pages: 602-614 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place Hoboken
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-008
DOI 10.1111/all.13312
WOS ID WOS:000425622700011
PubMed ID 28960325
Erfassungsdatum 2017-10-01
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