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Symvoulidis, P. ; Lauri, A. ; Stefanoiu, A.* ; Cappetta, M. ; Schneider, S.* ; Jia, H.* ; Stelzl, A. ; Koch, M. ; Perez, C.C. ; Myklatun, A. ; Renninger, S.* ; Chmyrov, A. ; Lasser, T.* ; Wurst, W. ; Ntziachristos, V. ; Westmeyer, G.G.

NeuBtracker-imaging neurobehavioral dynamics in freely behaving fish.

Nat. Methods 14, 1079-1082 (2017)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
A long-standing objective in neuroscience has been to image distributed neuronal activity in freely behaving animals. Here we introduce NeuBtracker, a tracking microscope for simultaneous imaging of neuronal activity and behavior of freely swimming fluorescent reporter fish. We showcase the value of NeuBtracker for screening neurostimulants with respect to their combined neuronal and behavioral effects and for determining spontaneous and stimulus-induced spatiotemporal patterns of neuronal activation during naturalistic behavior.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Light-sheet Microscopy; Brain Activity; Embryonic-development; Neuronal-activity; Larval Zebrafish; Neural Activity; Perception; Receptor
Language english
Publication Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 1548-7091
e-ISSN 1548-7105
Journal Nature Methods
Quellenangaben Volume: 14, Issue: 11, Pages: 1079-1082 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
Institute of Developmental Genetics (IDG)
POF-Topic(s) 30505 - New Technologies for Biomedical Discoveries
30502 - Diabetes: Pathophysiology, Prevention and Therapy
30204 - Cell Programming and Repair
Research field(s) Enabling and Novel Technologies
Genetics and Epidemiology
PSP Element(s) G-552000-001
G-552000-002
G-500500-001
PubMed ID 28967889
DOI 10.1038/nmeth.4459
WOS ID WOS:000414120400021
Scopus ID 85032575084
Erfassungsdatum 2017-10-11
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