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Fuchs, H. ; Aguilar-Pimentel, A. ; Amarie, O.V. ; Becker, L. ; Calzada-Wack, J. ; Cho, Y.-L. ; Garrett, L. ; Hölter, S.M. ; Irmler, M. ; Kistler, M. ; Kraiger, M. ; Mayer-Kuckuk, P. ; Moreth, K. ; Rathkolb, B. ; Rozman, J. ; da Silva Buttkus, P. ; Treise, I. ; Zimprich, A. ; Gampe, K. ; Hutterer, C. ; Leuchtenberger, S. ; Maier, H. ; Miller, M. ; Scheideler, A. ; Wu, M. ; Beckers, J. ; Bekeredjian, R.* ; Brielmeier, M. ; Busch, D.H.* ; Klingenspor, M.* ; Klopstock, T.* ; Ollert, M.* ; Schmidt-Weber, C.B. ; Stöger, T. ; Wolf, E.* ; Wurst, W. ; Yildirim, A.Ö. ; Zimmer, A.* ; Gailus-Durner, V. ; Hrabě de Angelis, M.

Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic.

Behav. Brain Res. 352, 187-196 (2017)
Postprint DOI PMC
Open Access Green
Since decades, model organisms have provided an important approach for understanding the mechanistic basis of human diseases. The German Mouse Clinic (GMC) was the first phenotyping facility that established a collaboration-based platform for phenotype characterization of mouse lines. In order to address individual projects by a tailor-made phenotyping strategy, the GMC advanced in developing a series of pipelines with tests for the analysis of specific disease areas. For a general broad analysis, there is a screening pipeline that covers the key parameters for the most relevant disease areas. For hypothesis-driven phenotypic analyses, there are thirteen additional pipelines with focus on neurological and behavioral disorders, metabolic dysfunction, respiratory system malfunctions, immune-system disorders and imaging techniques. In this article, we give an overview of the pipelines and describe the scientific rationale behind the different test combinations.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Mouse Phenotyping ; Phenotyping Pipeline ; Mouse Model ; Gene Function Analysis; Parkinsons-disease; Mice; Models; Homeostasis; Consortium; Disorders; Infection; Platform
ISSN (print) / ISBN 0166-4328
e-ISSN 1872-7549
Journal Behavioural Brain Research
Quellenangaben Volume: 352, Issue: , Pages: 187-196 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Po Box 211, 1000 Ae Amsterdam, Netherlands
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
Lung Health and Immunity (LHI)
Institute of Lung Biology (LHI)
Institute of Developmental Genetics (IDG)
CF Comparative Medicine (CF-Comparative Medicine)
Institute for Allergy Research (IAF)