Clues to quality of journals
Open Access Policy of Helmholtz Association 2016
CC Licencences
Publication Metrics
Home
Deutsch
New EVA Application
Advanced Search
Browse by ...
Publication overview
Statistics (last 5 years)
OA Publications
Submit Publication
Import publication from...
Report missing publication
Contact persons
Help
Text
Endnote (RIS)
BibTeX
Publ. Version/Full Text
Postprint
Research data
DOI
PMC
 |
Open Access Green |
as soon as is submitted to ZB.
Fifteen genetic loci associated with the electrocardiographic P wave.
Circ. Cardiovasc. Genet. 10:e001667 (2017)
Publ. Version/Full Text
Postprint
Research data
DOI
PMC
The P wave on an ECG is a measure of atrial electric function, and its characteristics may serve as predictors for atrial arrhythmias. Increased mean P-wave duration and P-wave terminal force traditionally have been used as markers for left atrial enlargement, and both have been associated with increased risk of atrial fibrillation. Here, we explore the genetic basis of P-wave morphology through meta-analysis of genome-wide association study results for P-wave duration and P-wave terminal force from 12 cohort studies. Methods and Results - We included 44 456 individuals, of which 6778 (16%) were of African ancestry. Genotyping, imputation, and genome-wide association study were performed at each study site. Summary-level results were meta-analyzed centrally using inverse-variance weighting. In meta-analyses of P-wave duration, we identified 6 significant (P < 5×10 -8 ) novel loci and replicated a prior association with SCN10A. We identified 3 loci at SCN5A, TBX5, and CAV1/CAV2 that were jointly associated with the PR interval, PR segment, and P-wave duration. We identified 6 novel loci in meta-analysis of P-wave terminal force. Four of the identified genetic loci were significantly associated with gene expression in 329 left atrial samples. Finally, we observed that some of the loci associated with the P wave were linked to overall atrial conduction, whereas others identified distinct phases of atrial conduction. Conclusions - We have identified 6 novel genetic loci associated with P-wave duration and 6 novel loci associated with P-wave terminal force. Future studies of these loci may aid in identifying new targets for drugs that may modify atrial conduction or treat atrial arrhythmias.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
4.743
1.227
1
27
Annotations
Special Publikation
Hide on homepage
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Arrhythmia ; Atrial Function ; Electrocardiography ; Genetic Variation ; Genome-wide Association Study
Language
english
Publication Year
2017
HGF-reported in Year
2017
ISSN (print) / ISBN
1942-325X
e-ISSN
1942-3268
Quellenangaben
Volume: 10,
Issue: 4,
Article Number: e001667
Publisher
Lippincott Williams & Wilkins
Publishing Place
Hagerstown, Md
Reviewing status
Peer reviewed
Institute(s)
Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology (EPI)
Institute of Human Genetics (IHG)
Institute of Epidemiology (EPI)
Institute of Human Genetics (IHG)
POF-Topic(s)
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30202 - Environmental Health
30202 - Environmental Health
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-504100-001
G-504000-001
G-504091-001
G-500700-001
G-504000-001
G-504091-001
G-500700-001
Scopus ID
85028918298
PubMed ID
28794112
Erfassungsdatum
2017-10-05