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Johnston, B.D. ; Kreyling, W.G. ; Pfeiffer, C.* ; Schäffler, M. ; Sarioglu, H. ; Ristig, S.* ; Hirn, S. ; Haberl, N. ; Thalhammer, S. ; Hauck, S.M. ; Semmler-Behnke, M. ; Epple, M.* ; Hühn, J.* ; del Pino, P.* ; Parak, W.J.*

Colloidal stability and surface chemistry are key factors for the composition of the protein corona of inorganic gold nanoparticles.

Adv. Func. Mat. 27:1701956 (2017)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
To study the influence of colloidal stability on protein corona formation, gold nanoparticles are synthesized with five distinct surface modifications: coating with citric acid, bis(p-sulfonatophenyl)phenylphosphine dihydrate dipotassium salt, thiol-terminated methoxy-polyethylene glycol, dodecylamine-grafted poly(isobutylene-alt-maleic anhydride), and dodecylamine-grafted poly(isobutylene-alt-maleic anhydride) conjugated with polyethylene glycol. The nanoparticles are incubated with serum or bronchoalveolar lavage fluid from C57BL/6 mice (15 min or 24 h) to assess the effect of differential nanoparticle surface presentation on protein corona formation in the air–blood barrier exposure pathway. Proteomic quantification and nanoparticle size measurements are used to assess protein corona formation. We show that surface modification has a clear effect on the size and the composition of the protein corona that is related to the colloidal stability of the studied nanoparticles. Additionally, differences in the composition and size of the protein corona are shown between biological media and duration of exposure, indicating evolution of the corona through this exposure pathway. Consequently, a major determinant of protein corona formation is the colloidal stability of nanoparticles in biological media and chemical or environmental modification of the nanoparticles alters the surface presentation of the functional epitope in vivo. Therefore, the colloidal stability of nanoparticles has a decisive influence on nano–bio interactions.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Colloidal Stability ; Gold Nanoparticles ; Protein Coronas ; Surface Chemistry Dependence; Adsorption; Cells; Electrophoresis; Polymer; Target; Size; Peg
Language english
Publication Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 1616-301X
e-ISSN 1616-3028
Journal Advanced functional materials
Quellenangaben Volume: 27, Issue: 42, Pages: , Article Number: 1701956 Supplement: ,
Publisher Wiley
Publishing Place Weinheim
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
CF Metabolomics & Proteomics (CF-MPC)
Institute of Lung Health and Immunity (LHI)
Institute of Radiation Protection (ISS)
POF-Topic(s) 30202 - Environmental Health
30203 - Molecular Targets and Therapies
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Genetics and Epidemiology
Enabling and Novel Technologies
Lung Research
Radiation Sciences
PSP Element(s) G-504000-001
G-505700-001
G-505000-001
G-501100-006
DOI 10.1002/adfm.201701956
WOS ID WOS:000414719300020
Scopus ID 85030317404
Erfassungsdatum 2017-10-05
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