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Azimzadeh, O. ; Tapio, S.

Proteomics landscape of radiation-induced cardiovascular disease: Somewhere over the paradigm.

Expert Rev. Proteomics 14, 987-996 (2017)
Postprint DOI PMC
Open Access Green
Introduction: Epidemiological studies clearly show that thoracic or whole body exposure to ionizing radiation increases the risk of cardiac morbidity and mortality. Radiation-induced cardiovascular disease (CVD) has been intensively studied during the last ten years but the underlying molecular mechanisms are still poorly understood. Areas covered: Heart proteomics is a powerful tool holding promise for the future research. The central focus of this review is to compare proteomics data on radiation-induced CVD with data arising from proteomics of healthy and diseased cardiac tissue in general. In this context we highlight common and unique features of radiation-related and other heart pathologies. Future prospects and challenges of the field are discussed. Expert commentary: Data from comprehensive cardiac proteomics have deepened the knowledge of molecular mechanisms involved in radiation-induced cardiac dysfunction. State-of-the-art proteomics has the potential to identify novel diagnostic and therapeutic markers of this disease.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Endothelial Cell ; Fibrates ; Heart ; Ionizing Radiation ; Label-free ; Ppar Alpha ; Proteomics ; Radiation Therapy ; Statins; Activated Receptor-alpha; Ischemic-heart-disease; Fatty-acid Oxidation; Extracellular-matrix Proteomics; Microvascular Endothelial-cells; Alkaline-phosphatase Activity; Cardiac Energy-metabolism; Myosin Heavy-chain; Low-dose Rate; Ionizing-radiation
Language
Publication Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 1478-9450
e-ISSN 1744-8387
Journal Expert Review of Proteomics
Quellenangaben Volume: 14, Issue: 11, Pages: 987-996 Article Number: , Supplement: ,
Publisher Expert Reviews
Publishing Place Abingdon
Reviewing status Peer reviewed
Institute(s) Institute of Radiation Biology (ISB)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Radiation Sciences
PSP Element(s) G-500200-001
DOI 10.1080/14789450.2017.1388743
WOS ID WOS:000418475000003
Scopus ID 85045060331
PubMed ID 28976223
Erfassungsdatum 2017-10-12
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