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Open Access Green as soon as Postprint is submitted to ZB.
The quest for more research on painful diabetic neuropathy.
Neuroscience, DOI: 10.1016/j.neuroscience.2017.09.023 (2017)
IBRO. A 62-year-old diabetologist diagnosed himself to have diabetes type-2, with an HbA1c of 9.5. Five months after lifestyle intervention and a multi-drug approach, HbA1c was 6.3, systolic blood pressure was below 135. mmHg and BMI reduced to 27. But he suffered from severe painful diabetic neuropathy. Therefore he decided to visit his friend, a famous neuroscientist at an even more famous university. He asked him several plain questions: 1. What is the natural course of painful diabetic neuropathy? 2. Why do I have, despite almost normalizing HbA1c, more problems than before? 3. Are you sure my problems are due to diabetes or should we do a nerve biopsy? 4. Are there imaging techniques helpful for the diagnosis of this diabetic complication, starting in the distal nerve endings of the foot and slowly moving ahead? 5. Can you suggest any drug, specific and effective, for relieving painful diabetic neuropathy?This review will use the experts' answers to the questions of the diabetologist, not only to give a summary of the current knowledge, but even more to highlight areas of research needed for improving the fate of patients with painful diabetic neuropathy. Based on the unknowns, which exceed the knowns in diabetic neuropathy, a quest for more public support of research is made.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Painful Diabetic Neuropathy ; Patho-mechanisms of Diabetic Neuropathy
Language
Publication Year
2017
HGF-reported in Year
2017
ISSN (print) / ISBN
0306-4522
e-ISSN
1873-7544
Journal
Neuroscience
Publisher
International Brain Research Organization, Elsevier
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Cancer (IDC)
POF-Topic(s)
90000 - German Center for Diabetes Research
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-501900-251
PubMed ID
28942323
Scopus ID
85030650773
Erfassungsdatum
2017-10-18