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Brix, N.* ; Tiefenthaller, A.* ; Anders, H.J.* ; Belka, C. ; Lauber, K.

Abscopal, immunological effects of radiotherapy: Narrowing the gap between clinical and preclinical experiences.

Immunol. Rev. 280, 249-279 (2017)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Immunological Reviews Published by John Wiley & Sons Ltd. Radiotherapy—despite being a local therapy that meanwhile is characterized by an impressively high degree of spatial accuracy—can stimulate systemic phenomena which occasionally lead to regression and rejection of non-irradiated, distant tumor lesions. These abscopal effects of local irradiation have been observed in sporadic clinical case reports since the beginning of the 20th century, and extensive preclinical work has contributed to identify systemic anti-tumor immune responses as the underlying driving forces. Although abscopal tumor regression still remains a rare event in the radiotherapeutic routine, increasing numbers of cases are being reported, particularly since the clinical implementation of immune checkpoint inhibiting agents. Accordingly, interests to systematically exploit the therapeutic potential of radiotherapy-stimulated systemic responses are constantly growing. The present review briefly delineates the history of radiotherapy-induced abscopal effects and the activation of systemic anti-tumor immune responses by local irradiation. We discuss preclinical and clinical reports with specific focus on the corresponding controversies, and we propose issues that should be addressed in the future in order to narrow the gap between preclinical knowledge and clinical experiences.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Abscopal Effect ; Anti-tumor Immunity ; Immunogenic Cell Death ; Radiotherapy; Colony-stimulating Factor; Cell Lung-cancer; Cd8(+) T-cells; Whole-breast Radiotherapy; Melanoma Brain Metastases; Local Tumor-irradiation; Radiation-therapy Iort; Gcv Gene-therapy; Antitumor Immunity; Spontaneous Regression
ISSN (print) / ISBN 0105-2896
e-ISSN 1600-065X
Journal Immunological Reviews
Quellenangaben Volume: 280, Issue: 1, Pages: 249-279 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place Hoboken
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Translational Metabolic Oncology (IDC-TMO)