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Meles, S.K.* ; Vadasz, D.* ; Renken, R.J.* ; Sittig-Wiegand, E.* ; Mayer, G.* ; Depboylu, C.* ; Reetz, K.* ; Overeem, S.* ; Pijpers, A.* ; Reesink, F.E.* ; van Laar, T.* ; Heinen, L.* ; Teune, L.K.* ; Höffken, H.* ; Luster, M.* ; Kesper, K.* ; Adriaanse, S.M.* ; Booij, J.* ; Leenders, K.L.* ; Oertel, W.H.

FDG PET, dopamine transporter SPECT, and olfaction: Combining biomarkers in REM sleep behavior disorder.

Mov. Disord. 32, 1482-1486 (2017)

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Open Access Green as soon as Postprint is submitted to ZB.

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BACKGROUND: Idiopathic REM sleep behavior disorder is a prodromal stage of Parkinson's disease and dementia with Lewy bodies. Hyposmia, reduced dopamine transporter binding, and expression of the brain metabolic PD-related pattern were each associated with increased risk of conversion to PD. The objective of this study was to study the relationship between the PD-related pattern, dopamine transporter binding, and olfaction in idiopathic REM sleep behavior disorder. METHODS: In this cross-sectional study, 21 idiopathic REM sleep behavior disorder subjects underwent ¹⁸ F-fluorodeoxyglucose PET, dopamine transporter imaging, and olfactory testing. For reference, we included ¹⁸ F-fluorodeoxyglucose PET data of 19 controls, 20 PD patients, and 22 patients with dementia with Lewy bodies. PD-related pattern expression z-scores were computed from all PET scans. RESULTS: PD-related pattern expression was higher in idiopathic REM sleep behavior disorder subjects compared with controls (P = 0.048), but lower compared with PD (P = 0.001) and dementia with Lewy bodies (P < 0.0001). PD-related pattern expression was higher in idiopathic REM sleep behavior disorder subjects with hyposmia and in subjects with an abnormal dopamine transporter scan (P < 0.05, uncorrected). CONCLUSION:

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords 18 F-fdg-pet ; Dopamine Transporter I-fp-cit Spect 123 ; Idiopathic Rem Sleep Behavior Disorder ; Olfaction ; Parkinson's Disease-related Pattern; Metabolic Network Activity; Parkinsons-disease; Neurodegenerative Disease; Brain Networks; Lewy Bodies; Diagnosis; Dementia; Abnormalities; Dysfunction

ISSN (print) / ISBN 0885-3185

e-ISSN 1531-8257

Journal Movement Disorders

Quellenangaben Volume: 32, Issue: 10, Pages: 1482-1486

Publisher Wiley

Publishing Place Hoboken

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Neurogenomics (ING)