PuSH - Publication Server of Helmholtz Zentrum München: Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population.

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

EVA: Electronic Publishing

New EVA Application

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Li, Y.* ; Xiao, X.* ; Han, Y.* ; Gorlova, O.* ; Qian, D.C.* ; Leighl, N.* ; Johansen, J.S.* ; Barnett, M.* ; Chen, C.* ; Goodman, G.* ; Cox, A.* ; Taylor, F.* ; Woll, P.* ; Wichmann, H.-E. ; Manz, J. ; Muley, T.* ; Risch, A.* ; Rosenberger, A.* ; Arnold, S.M.* ; Haura, E.B.* ; Bolca, C.* ; Holcatova, I.* ; Janout, V.* ; Kontic, M.* ; Lissowska, J.* ; Mukeria, A.* ; Ognjanovic, S.* ; Orlowski, T.M.* ; Scelo, G.* ; Swiatkowska, B.* ; Zaridze, D.* ; Bakke, P.* ; Skaug, V.* ; Zienolddiny, S.* ; Duell, E.J.* ; Butler, L.M.* ; Houlston, R.* ; Artigas, M.S.* ; Grankvist, K.* ; Johansson, M.* ; Shepherd, F.A.* ; Marcus, M.W.* ; Brunnström, H.* ; Manjer, J.* ; Melander, O.* ; Müller, D.C.* ; Overvad, K.* ; Trichopoulou, A.* ; Tumino, R.* ; Liu, G.* ; Bojesen, S.E.* ; Wu, X.* ; Le Marchand, L.* ; Albanes, D.* ; Bickeböller, H.* ; Aldrich, M.C.* ; Bush, W.S.* ; Tardón, A.* ; Rennert, G.* ; Teare, M.D.* ; Field, J.K.* ; Kiemeney, L.A.* ; Lazarus, P.* ; Haugen, A.* ; Lam, S.* ; Schabath, M.B.* ; Andrew, A.S.* ; Bertazzi, P.A.* ; Pesatori, A.C.* ; Christiani, D.C.* ; Caporaso, N.* ; McKay, J.D.* ; Brennan, P.* ; Hung, R.J.* ; Amos, C.I.*

Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population.

Carcinogenesis 39, 336-346 (2018)

Publ. Version/Full Text

Postprint

Research data

DOI

PMC

	Open Access Green

Abstract
Metrics
Extra information

Non-small cell lung cancer is the most common type of lung cancer. Both environmental and genetic risk factors contribute to lung carcinogenesis. We conducted a genome-wide interaction analysis between single nucleotide polymorphisms (SNPs) and smoking status (never-versus ever-smokers) in a European-descent population. We adopted a two-step analysis strategy in the discovery stage: we first conducted a case-only interaction analysis to assess the relationship between SNPs and smoking behavior using 13 336 non-small cell lung cancer cases. Candidate SNPs with P-value <0.001 were further analyzed using a standard case-control interaction analysis including 13 970 controls. The significant SNPs with P-value <3.5 x 10(-5) (correcting for multiple tests) from the case-control analysis in the discovery stage were further validated using an independent replication dataset comprising 5377 controls and 3054 non-small cell lung cancer cases. We further stratified the analysis by histological subtypes. Two novel SNPs, rs6441286 and rs17723637, were identified for overall lung cancer risk. The interaction odds ratio and meta-analysis P-value for these two SNPs were 1.24 with 6.96 x 10(-7) and 1.37 with 3.49 x 10(-7), respectively. In addition, interaction of smoking with rs4751674 was identified in squamous cell lung carcinoma with an odds ratio of 0.58 and P-value of 8.12 x 10(-7). This study is by far the largest genome-wide SNP-smoking interaction analysis reported for lung cancer. The three identified novel SNPs provide potential candidate biomarkers for lung cancer risk screening and intervention. The results from our study reinforce that gene-smoking interactions play important roles in the etiology of lung cancer and account for part of the missing heritability of this disease.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

5.072

1.266