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Open Access Green as soon as Postprint is submitted to ZB.
Histone propionylation is a mark of active chromatin.
Nat. Struct. Mol. Biol. 24, 1048–1056 (2017)
Histones are highly covalently modified, but the functions of many of these modifications remain unknown. In particular, it is unclear how histone marks are coupled to cellular metabolism and how this coupling affects chromatin architecture. We identified histone H3 Lys14 (H3K14) as a site of propionylation and butyrylation in vivo and carried out the first systematic characterization of histone propionylation. We found that H3K14pr and H3K14bu are deposited by histone acetyltransferases, are preferentially enriched at promoters of active genes and are recognized by acylation-state-specific reader proteins. In agreement with these findings, propionyl-CoA was able to stimulate transcription in an in vitro transcription system. Notably, genome-wide H3 acylation profiles were redefined following changes to the metabolic state, and deletion of the metabolic enzyme propionyl-CoA carboxylase altered global histone propionylation levels. We propose that histone propionylation, acetylation and butyrylation may act in combination to promote high transcriptional output and to couple cellular metabolism with chromatin structure and function.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Rna-polymerase-ii; Metabolic-regulation; Gene-expression; Transcription; Acetylation; Complex; Protein; Genome; Reconstitution; Butyrylation
ISSN (print) / ISBN
1545-9993
e-ISSN
1545-9985
Quellenangaben
Volume: 24,
Issue: 12,
Pages: 1048–1056
Publisher
Nature Publishing Group
Publishing Place
New York, NY
Non-patent literature
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Reviewing status
Peer reviewed