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Devillier, P.* ; Wahn, U.* ; Zielen, S.* ; Heinrich, J.

Grass pollen sublingual immunotherapy tablets provide long-term relief of grass pollen-associated allergic rhinitis and reduce the risk of asthma: Findings from a retrospective, real-world database subanalysis.

Expert Rev. Clin. Immunol. 13, 1199-1206 (2017)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
BACKGROUND: We assessed real-world, long-term effectiveness of two marketed sublingual immunotherapy (SLIT) tablets for allergic rhinitis (AR), and their impact on allergic asthma (AA) onset/progression. RESEARCH DESIGN AND METHODS: Retrospective, longitudinal German prescription database subanalysis of AR patients receiving 5- or 1-grass pollen SLIT tablets (n=1,466/1,385), versus patients not using allergy immunotherapy (AIT) (n=71,275). MAIN OUTCOME MEASURES: Primary endpoint: change over time in AR symptomatic medication prescriptions after treatment cessation; secondary endpoints: new asthma onset, and change over time in asthma medication prescriptions during treatment/follow-up periods. RESULTS: Mean number of AR medication prescriptions was significantly decreased during follow-up (of up to 6 years) with both SLIT tablets versus the non-AIT group (p<0.001). Over the full-analysis period, proportions of patients with new-onset asthma were 8.8% (odds ratio: 0.676, p=0.011), 10.3% (odds ratio: 0.720, p=0.060) and 11.6% in the 5- and 1-grass pollen SLIT tablet and non-AIT groups, respectively. For all treatment-analysis periods, both SLIT tablet groups were associated with fewer asthma medication prescriptions versus non-AIT controls. CONCLUSIONS: These findings confirm the real-world benefits of 5- and 1-grass-pollen SLIT tablets in slower AR progression, reduced risk of new asthma onset in the non-asthmatic population, and slower asthma progression in the asthmatic population.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Allergic Rhinitis ; Asthma ; Grass Pollen ; Real-world ; Sublingual Immunotherapy; Controlled-trials; Clinical-trials; Rhinoconjunctivitis; Collaboration; Prevalence; Consensus; Disease; Impact
ISSN (print) / ISBN 1744-666X
Journal Expert Review of Clinical Immunology
Quellenangaben Volume: 13, Issue: 12, Pages: 1199-1206 Article Number: , Supplement: ,
Publisher Expert Reviews
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)