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Herbert, A.* ; Gerry, N.P.* ; McQueen, M.B.* ; Heid, I.M. ; Pfeufer, A. ; Illig, T. ; Wichmann, H.-E. ; Meitinger, T. ; Hunter, D.* ; Hu, F.B.* ; Colditz, G.* ; Hinney, A.* ; Hebebrand, J.* ; Koberwitz, K.* ; Zhu, X.* ; Cooper, R.* ; Ardlie, K.* ; Lyon, H.* ; Hirschhorn, J.N.* ; Laird, N.M.* ; Lenburg, M.E.* ; Lange, C.* ; Christman, M.F.*

A common genetic variant is associated with adult and childhood obesity.

Science 312, 279-283 (2006)
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Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity. We have replicated the finding in four separate samples composed of individuals of Western European ancestry, African Americans, and children. The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2006
HGF-reported in Year 2006
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Journal Science
Quellenangaben Volume: 312, Issue: 5771, Pages: 279-283 Article Number: , Supplement: ,
Publisher American Association for the Advancement of Science (AAAS)
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Institute of Computational Biology (ICB)
Institute of Human Genetics (IHG)
POF-Topic(s) 30202 - Environmental Health
30205 - Bioengineering and Digital Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30503 - Chronic Diseases of the Lung and Allergies
Research field(s) Genetics and Epidemiology
Enabling and Novel Technologies
PSP Element(s) G-504000-007
G-503891-001
G-504091-001
G-504000-009
G-500700-001
G-503900-001
DOI 10.1126/science.1124779
Scopus ID 33645825830
Erfassungsdatum 2006-07-05
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