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Open Access Green as soon as Postprint is submitted to ZB.
An appetite for life: Brain regulation of hunger and satiety.
Curr. Opin. Pharmacol. 37, 100-106 (2017)
Obesity results from the consumption of food in excess of bodily energy requirements, with the excess energy stored as adipose tissue. Sequelae of obesity, such as heart disease and type 2 diabetes, consistently rank among the top causes of death worldwide. The global prevalence of obesity highlights the urgency of understanding the mechanisms regulating hunger and satiety. Appetite, defined as the motivational drive to obtain food, is regulated by a complex neurocircuitry which integrates a variety of interoceptive signals to gauge nutritional state and guide appropriate levels of food-seeking. Here we review key recent developments in the identification of cell groups, neural circuits, endogenous and exogenous substances, and intracellular signaling pathways which drive hunger and satiety. We also consider particularly promising pharmacological targets for appetite modulation.
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Scopus SNIP
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Times Cited
Times Cited
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Cited By
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5.363
1.482
41
58
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Publication type
Article: Journal article
Document type
Review
Keywords
Nucleus-tractus-solitarius; Food-intake; Agrp Neurons; Hypothalamic Neurons; Pomc Neurons; Body-weight; Feeding-behavior; Neural Circuits; Activation; Leptin
Language
english
Publication Year
2017
HGF-reported in Year
2017
ISSN (print) / ISBN
1471-4892
e-ISSN
1471-4973
Journal
Current opinion in pharmacology
Quellenangaben
Volume: 37,
Pages: 100-106
Publisher
Elsevier
Publishing Place
London
Reviewing status
Peer reviewed
Institute(s)
Institute of Neurogenomics (ING)
POF-Topic(s)
30205 - Bioengineering and Digital Health
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-503200-001
PubMed ID
29107871
WOS ID
WOS:000419423700017
Scopus ID
85032731166
Erfassungsdatum
2017-11-08