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Ludwig, B. ; Ludwig, S.* ; Steffen, A. ; Knauf, Y.* ; Zimerman, B.* ; Heinke, S.* ; Lehmann, S.* ; Schubert, U.* ; Schmid, J.* ; Bleyer, M.* ; Schoenmann, U.* ; Colton, C.K.* ; Bonifacio, E.* ; Solimena, M. ; Reichel, A.* ; Schally, A.V.* ; Rotem, A.* ; Barkai, U.* ; Grinberg-Rashi, H.* ; Kaup, F.* ; Avni, Y.* ; Jones, P.* ; Bornstein, S.R.

Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes.

Proc. Natl. Acad. Sci. U.S.A. 114, 11745-11750 (2017)

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Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macro-encapsulate islets from different sources that allow their survival and function without immunosuppression. Here we report successful and safe transplantation of porcine islets with a bioartificial pancreas device in diabetic primates without any immune suppression. This strategy should lead to pioneering clinical trials with xenotransplantation for treatment of diabetes and, thereby, represents a previously unidentified approach to efficient cell replacement for a broad spectrum of endocrine disorders and other organ dysfunctions.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Diabetes ; Porcine Islets ; Beta-cell Replacement ; Immune Barrier; Hormone-releasing-hormone; Beta-cell Replacement; Bioartificial Pancreas; Transplantation; Future; Minipigs; Agonists

ISSN (print) / ISBN 0027-8424

e-ISSN 1091-6490

Journal Proceedings of the National Academy of Sciences of the United States of America

Quellenangaben Volume: 114, Issue: 44, Pages: 11745-11750

Publisher National Academy of Sciences

Publishing Place Washington

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Pancreatic Islet Research (IPI)