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Dobiasch, S.* ; Goerig, N.L.* ; Fietkau, R.* ; Combs, S.E.

Essential role of radiation therapy for the treatment of pancreatic cancer.

Strahlenther. Onkol. 194, 185–195 (2018)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Pancreatic cancer is one of the most aggressive human tumors and the incidence has increased over the last 6 years. In the majority of cases the disease is already in an advanced stage at the time of diagnosis where surgery, the only curative treatment, is no longer an option and explains the still abysmal overall survival. The role of radiation therapy as treatment option for patients with pancreatic cancer is controversially discussed although radiation oncology has emerged as a central pillar in the combined oncological treatment. The present manuscript gives an overview of advanced radiotherapeutic strategies in the context of chemotherapy and surgery according to the current American Society of Clinical Oncology (ASCO) guidelines in comparison with the German guidelines and to elucidate the role of radiation therapy for the treatment of pancreatic cancer. Advanced modern radiotherapeutic techniques in combination with individualized high-precision radiation concepts are new therapeutic approaches for pancreatic cancer in a multimodal setting with tolerable side effects. Several clinical studies together with experimental approaches are in process, to deliver further evidence and ultimately allow true personalized medicine.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Intensity Modulated Radiotherapy ; Disease-free Survival ; Stereotactic Radiosurgery ; Clinical Studies ; Interdisciplinary Treatment; Stereotactic Body Radiotherapy; Gemcitabine-based Chemoradiation; Clinical-practice Guideline; Phase-iii Trial; Neoadjuvant Chemoradiation; Intraoperative Radiotherapy; Resectable Adenocarcinoma; Preoperative Gemcitabine; Retrospective Analysis; Adjuvant Radiotherapy
Language
Publication Year 2018
Prepublished in Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 0179-7158
e-ISSN 1439-099X
Journal Strahlentherapie und Onkologie : Journal of Radiation Oncology, Biology, Physics
Quellenangaben Volume: 194, Issue: 3, Pages: 185–195 Article Number: , Supplement: ,
Publisher Urban & Vogel
Publishing Place Heidelberg
Reviewing status Peer reviewed
Institute(s) Institute of Radiation Medicine (IRM)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Radiation Sciences
PSP Element(s) G-501300-001
DOI 10.1007/s00066-017-1227-5
WOS ID WOS:000425741600001
Scopus ID 85032901648
PubMed ID 29094172
Erfassungsdatum 2017-11-15
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